MPP7 - MAGUK p55 scaffold protein 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 143098

About MPP7

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:28,050,993-28,335,203 (from NCBI)

This gene has 9 transcripts (splice variants), 225 orthologues and 7 paralogues. Ubiquitous expression in esophagus (RPKM 17.1), skin (RPKM 11.1) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

MPP7 Products (2)

mRNA Protein Name
NM_001318170.2 NP_001305099.1 MAGUK p55 subfamily member 7
NM_173496.5 NP_775767.2 MAGUK p55 subfamily member 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
17237226 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17237226 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17332497 GOA
Biological Process GO Annotation Evidence References Source
involved in bicellular tight junction assembly IDA
IDA: Inferred from direct assay
17332497 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
17237226 GOA
involved in protein localization to adherens junction IMP
IMP: Inferred from mutant phenotype
17237226 GOA
Cellular Component GO Annotation Evidence References Source
part of MPP7-DLG1-LIN7 complex IDA
IDA: Inferred from direct assay
17237226 GOA
located in adherens junction IDA
IDA: Inferred from direct assay
17237226 GOA
located in bicellular tight junction IDA
IDA: Inferred from direct assay
17332497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPP7 Protein Structure

L27

L27: L27 domain (13 - 67)

L27

L27: L27 domain (78 - 125)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (141 - 216)

SH3_2

SH3_2: Variant SH3 domain (232 - 295)

Guanylate_kin

Guanylate_kin: Guanylate kinase (368 - 560)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
Protein Preferred Names Protein Names

MAGUK p55 subfamily member 7

  • membrane palmitoylated protein 7

MPP7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MPP7 Q5T2T1 LIN7C Homo sapiens Q9NUP9
Validated Y2H
32296183
Intra
MPP7 Q5T2T1 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
Intra
MPP7 Q5T2T1 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Prey Pooling
32296183
Intra
MPP7 Q5T2T1 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Array
32296183
Intra
MPP7 Q5T2T1 MYSM1 Homo sapiens Q5VVJ2
Y2H Prey Pooling
32296183
Intra
MPP7 Q5T2T1 MYSM1 Homo sapiens Q5VVJ2
Validated Y2H
32296183
Intra
MPP7 Q5T2T1 MYSM1 Homo sapiens Q5VVJ2
Y2H Array
32296183
Intra
MPP7 Q5T2T1 TRIM5 Homo sapiens Q9C035-3
Validated Y2H
32296183
Intra
MPP7 Q5T2T1 TRIM5 Homo sapiens Q9C035-3
Y2H Prey Pooling
32296183
Intra
MPP7 Q5T2T1 LIN7A Homo sapiens O14910
Y2H Prey Pooling
32296183
Intra
MPP7 Q5T2T1 LIN7A Homo sapiens O14910
Y2H Array
32296183
Intra
MPP7 Q5T2T1 LIN7B Homo sapiens Q9HAP6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02595 CHAF1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08626 MPP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MPP7 MGD MGI:1922989
Macaca mulatta MPP7 VGNC VGNC:74835
Bos taurus MPP7 VGNC VGNC:31586
Rattus norvegicus MPP7 RGD RGD:1305675
Canis familiaris MPP7 VGNC VGNC:49833
Felis catus MPP7 VGNC VGNC:97517
Others MPP7 NCBI