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LIN7C - lin-7 homolog C, crumbs cell polarity complex component Gene

Also Known as MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55327

About LIN7C

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:27,494,418-27,506,769 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 9.8), liver (RPKM 7.0) and 25 other tissues.

Summary

Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex. [provided by Alliance of Genome Resources, Apr 2022]

LIN7C Products (1)

mRNA	Protein	Name
NM_018362.4	NP_060832.1	protein lin-7 homolog C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L27 domain binding	IDA IDA: Inferred from direct assay	20702775	GOA
enables cytoskeletal protein binding	IPI IPI: Inferred from physical interaction	17987659	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21849460	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17237226	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	23201090	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MPP7-DLG1-LIN7 complex	IDA IDA: Inferred from direct assay	20702775	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	23201090	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	23201090	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21849460	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN7C Protein Structure

L27

PDZ

0
100
197 a.a.

Protein Preferred Names	Protein Names
protein lin-7 homolog C	LIN-7 protein 3

LIN7C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LIN7C	Q9NUP9	MPP2	Homo sapiens	Q14168-4	Y2H Prey Pooling	32296183
Intra	LIN7C	Q9NUP9	MPP2	Homo sapiens	Q14168-4	Y2H Array	32296183
Intra	LIN7C	Q9NUP9	MPP7	Homo sapiens	Q5T2T1	Y2H Prey Pooling	32296183
Intra	LIN7C	Q9NUP9	MPP7	Homo sapiens	Q5T2T1	Y2H Array	32296183
Intra	LIN7C	Q9NUP9	MPP7	Homo sapiens	Q5T2T1	Anti Tag CoIP	33961781
Intra	LIN7C	Q9NUP9	MPP7	Homo sapiens	Q5T2T1	Anti Tag CoIP	28514442
Intra	LIN7C	Q9NUP9	PALS2	Homo sapiens	Q9NZW5	Y2H Prey Pooling	32296183
Intra	LIN7C	Q9NUP9	PALS2	Homo sapiens	Q9NZW5	Validated Y2H	32296183
Intra	LIN7C	Q9NUP9	PALS2	Homo sapiens	Q9NZW5	Y2H Array	32296183
Intra	LIN7C	Q9NUP9	PALS2	Homo sapiens	Q9NZW5	Anti Tag CoIP	33961781
Intra	LIN7C	Q9NUP9	PALS2	Homo sapiens	Q9NZW5	Anti Tag CoIP	28514442
Intra	LIN7C	Q9NUP9	MPP3	Homo sapiens	Q13368	Anti Tag CoIP	33961781
Intra	LIN7C	Q9NUP9	MPP3	Homo sapiens	Q13368	Y2H Array	32296183
Intra	LIN7C	Q9NUP9	MPP3	Homo sapiens	Q13368	Anti Tag CoIP	28514442
Intra	LIN7C	Q9NUP9	MPP3	Homo sapiens	Q13368	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome	Wagr Syndrome 11p Partial Monosomy Syndrome Chromosome 11p13 Deletion Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome 11p Deletion Syndrome Chromosome 11p Deletion Syndrome Wagr Complex Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome Deletion 11p13 WAGR Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Chromosome 11p Deletion 11p Deletion 11p Monosomy Deletion 11p Monosomy 11p Partial Monosomy 11p Agr Triad Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome Wagr Contiguous Gene Syndrome Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome Del(11)(P13) Monosomy 11p13 Chromosome 11, Deletion 11p

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07678	LIN7C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LIN7C	VGNC	VGNC:82034
Macaca mulatta	LIN7C	VGNC	VGNC:74070
Mus musculus	LIN7C	MGD	MGI:1330839
Rattus norvegicus	LIN7C	RGD	RGD:621164
Bos taurus	LIN7C	VGNC	VGNC:30897