PALS1 - protein associated with LIN7 1, MAGUK p55 family member Gene

Also Known as MPP5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64398

About PALS1

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:67,241,435-67,336,061 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 15.8), thyroid (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

PALS1 Products (2)

mRNA	Protein	Name
NM_001256550.2	NP_001243479.1	protein PALS1 isoform 2
NM_022474.4	NP_071919.2	protein PALS1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15914641	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11927608	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17332497	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in morphogenesis of an epithelial sheet	IMP IMP: Inferred from mutant phenotype	23201090	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	15914641	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	15914641	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PALS1 Protein Structure

L27_N

L27

PDZ

SH3_2

Guanylate_kin

0
200
400
600
675 a.a.

Protein Preferred Names	Protein Names
protein PALS1	MAGUK p55 subfamily member 5

PALS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PALS1	Q8N3R9	FTCD	Homo sapiens	O95954	Y2H Array	32296183
Intra	PALS1	Q8N3R9	FTCD	Homo sapiens	O95954	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	EPB41L5	Homo sapiens	Q9HCM4	Y2H	17920587
Intra	PALS1	Q8N3R9	EPB41L5	Homo sapiens	Q9HCM4	Pull Down	17920587
Intra	PALS1	Q8N3R9	EPB41L5	Homo sapiens	Q9HCM4	Anti Bait CoIP	17920587
Intra	PALS1	Q8N3R9	CRB1	Homo sapiens	P82279	SPR	33758649
Intra	PALS1	Q8N3R9	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	PALS1	Q8N3R9	LIN7C	Homo sapiens	Q9NUP9	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	LIN7C	Homo sapiens	Q9NUP9	Anti Tag CoIP	24366813
Intra	PALS1	Q8N3R9	LIN7C	Homo sapiens	Q9NUP9	Anti Tag CoIP	33961781
Intra	PALS1	Q8N3R9	LIN7C	Homo sapiens	Q9NUP9	Validated Y2H	32296183
Intra	PALS1	Q8N3R9	LIN7C	Homo sapiens	Q9NUP9	Y2H Array	32296183
Intra	PALS1	Q8N3R9	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Array	32296183
Intra	PALS1	Q8N3R9	DLGAP4	Homo sapiens	Q9Y2H0-1	Validated Y2H	32296183
Intra	PALS1	Q8N3R9	DLGAP4	Homo sapiens	Q9Y2H0-1	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	SRGAP2B	Homo sapiens	A0A286YEY3	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	SRGAP2B	Homo sapiens	A0A286YEY3	Y2H Array	32296183
Intra	PALS1	Q8N3R9	SNTG2	Homo sapiens	Q9NY99-2	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	SNTG2	Homo sapiens	Q9NY99-2	Validated Y2H	32296183
Intra	PALS1	Q8N3R9	SNTG2	Homo sapiens	Q9NY99-2	Y2H Array	32296183
Intra	PALS1	Q8N3R9	MPP4	Homo sapiens	Q96JB8	Pull Down	15914641
Intra	PALS1	Q8N3R9	MPP4	Homo sapiens	Q96JB8	Y2H	15914641
Intra	PALS1	Q8N3R9	MPP4	Homo sapiens	Q96JB8	Anti Bait CoIP	15914641
Intra	PALS1	Q8N3R9	MPP4	Homo sapiens	Q96JB8	Anti Tag CoIP	15914641
Intra	PALS1	Q8N3R9	LIN7A	Homo sapiens	O14910	Anti Tag CoIP	33961781
Cross	PALS1	Q8N3R9	E	SARS-CoV-2	P0DTC4	MST	34103506
Intra	PALS1	Q8N3R9	AMOT	Homo sapiens	Q4VCS5	Anti Tag CoIP	24366813
Cross	PALS1	Q8N3R9	E	SARS-CoV-2	P0DTC4	3D-EM	34103506
Cross	PALS1	Q8N3R9	E	SARS-CoV-2	P0DTC4	2D-IR	32822073
Intra	PALS1	Q8N3R9	LIN7A	Homo sapiens	O14910	Validated Y2H	25416956
Intra	PALS1	Q8N3R9	LIN7A	Homo sapiens	O14910	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	LIN7A	Homo sapiens	O14910	Anti Tag CoIP	24366813
Cross	PALS1	Q8N3R9	E	SARS-CoV-2	P0DTC4	FRET	32822073
Intra	PALS1	Q8N3R9	AMOT	Homo sapiens	Q4VCS5	Anti Tag CoIP	33961781
Intra	PALS1	Q8N3R9	LIN7A	Homo sapiens	O14910	Y2H Array	25416956
Cross	PALS1	Q8N3R9	E	SARS-CoV-2	P0DTC4	SPR	33758649
Intra	PALS1	Q8N3R9	LIN7A	Homo sapiens	O14910	Y2H Array	32296183
Intra	PALS1	Q8N3R9	AMOT	Homo sapiens	Q4VCS5	Anti Tag CoIP	21481793
Cross	PALS1	Q8N3R9	E	Human SARS coronavirus	P59637	SPR	33758649
Cross	PALS1	Q8N3R9	E	Human SARS coronavirus	P59637	2D-IR	32822073
Cross	PALS1	Q8N3R9	E	Human SARS coronavirus	P59637	FRET	32822073
Intra	PALS1	Q8N3R9	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	PALS1	Q8N3R9	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	PALS1	Q8N3R9	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	PALS1	Q8N3R9	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	PALS1	Q8N3R9	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	PALS1	Q8N3R9	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	PALS1	Q8N3R9	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	PALS1	Q8N3R9	PATJ	Homo sapiens	Q8NI35	Anti Tag CoIP	33961781
Intra	PALS1	Q8N3R9	PATJ	Homo sapiens	Q8NI35	Anti Tag CoIP	24366813
Intra	PALS1	Q8N3R9	PATJ	Homo sapiens	Q8NI35	Anti Tag CoIP	21481793
Intra	PALS1	Q8N3R9	LIN7B	Homo sapiens	Q9HAP6	Y2H Prey Pooling	32296183
Intra	PALS1	Q8N3R9	LIN7B	Homo sapiens	Q9HAP6	Validated Y2H	32296183
Intra	PALS1	Q8N3R9	LIN7B	Homo sapiens	Q9HAP6	Y2H Array	32296183
Intra	PALS1	Q8N3R9	LIN7B	Homo sapiens	Q9HAP6	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Arachnoid Cysts, Intracranial	Arachnoid Cyst Arachnoid Cysts Intracranial Arachnoid Cysts Arachnoid Brain Cyst Arachnoid Cerebral Cyst Intracranium Cyst Nos
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Non-Specific Syndromic Intellectual Disability	Complex Neurodevelopmental Disorder
Retinitis Pigmentosa 12	RP12 Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium Rp With Or Without Pprpe Retinitis Pigmentosa-12
Retinal Degeneration	Degeneration Of Retina
Intraorbital Meningioma
Endometrial Adenosquamous Carcinoma	Adenosquamous Carcinoma Of Endometrium Adenosquamous Carcinoma Of The Endometrium Endometrial Adenosquamous Cancer Endometrial Adenosquamous Cell Carcinoma
Nephronophthisis 7	NPHP7 Nephronophthisis, Type 7
Leber Congenital Amaurosis 8	LCA8 Leber Congenital Amaurosis, Type 8
Central Sleep Apnea	Central Sleep Apnea Syndrome Sleep Apnea, Central Primary Central Sleep Apnea Central Sleep Apnea, Primary Central Sleep Apnoea Syndrome Csa - [Central Sleep Apnoea] Csas - [Central Sleep Apnoea Syndrome] Central Sleep Apnoea Due To Substances Including Medications
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Late-Onset Retinal Degeneration	LORD Retinal Degeneration, Late-Onset, Autosomal Dominant Autosomal Dominant Late-Onset Retinal Degeneration Pigmentary Retinopathy Retinal Degeneration, Late-Onset Retinitis Pigmentosa
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177596A	Dicytidine 5′-triphosphate trisodium	Activator	/	Unkown
HY-RS10009	PALS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177596	Dicytidine 5′-triphosphate	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PALS1	RGD	RGD:1308071
Macaca mulatta	PALS1	VGNC	VGNC:74794
Canis familiaris	PALS1	VGNC	VGNC:43346
Felis catus	PALS1	VGNC	VGNC:80910
Bos taurus	PALS1	VGNC	VGNC:31584
Mus musculus	PALS1	MGD	MGI:1927339
Others	PALS1	NCBI