SNX9 - sorting nexin 9 Gene

Also Known as SDP1; WISP; SH3PX1; SH3PXD3A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51429

About SNX9

Cytogenetic location: 6q25.3 Genomic coordinates (GRCh38): 6:157,823,246-157,945,077 (from NCBI)

This gene has 23 transcripts (splice variants), 252 orthologues and 15 paralogues. Ubiquitous expression in gall bladder (RPKM 27.0), esophagus (RPKM 26.7) and 25 other tissues.

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a Src homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2 , Dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation. [provided by RefSeq, Jul 2013]

SNX9 Products (1)

mRNA	Protein	Name
NM_016224.5	NP_057308.1	sorting nexin-9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 1-phosphatidylinositol binding	IDA IDA: Inferred from direct assay	17948057	GOA
enables Arp2/3 complex binding	IDA IDA: Inferred from direct assay	18388313	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	18940612	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	18388313	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10531379	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	17948057	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	20491914	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cleavage furrow formation	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in endosomal transport	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	15703209	GOA
involved in lipid tube assembly	IDA IDA: Inferred from direct assay	17948057	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	22718350	GOA
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	18388313	GOA
involved in positive regulation of GTPase activity	IDA IDA: Inferred from direct assay	15703209	GOA
involved in positive regulation of membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	18353773	GOA
involved in positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	18388313	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	15703209	GOA
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	15703209	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	15703209	GOA
colocalizes with clathrin-coated vesicle	IDA IDA: Inferred from direct assay	15703209	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18388313	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	15703209	GOA
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	17948057	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18388313	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	15703209	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNX9 Protein Structure

SH3_1

BAR_3_WASP_bdg

0
100
200
300
400
500
595 a.a.

Protein Preferred Names	Protein Names
sorting nexin-9	SH3 and PX domain-containing protein 1

SNX9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SNX9	Q9Y5X1	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	20491914
Intra	SNX9	Q9Y5X1	ITCH	Homo sapiens	Q96J02	Anti Bait CoIP	20491914
Intra	SNX9	Q9Y5X1	ITCH	Homo sapiens	Q96J02	Pull Down	20491914
Intra	SNX9	Q9Y5X1	SOS1	Homo sapiens	Q07889	CoIP	14679214
Intra	SNX9	Q9Y5X1	SOS1	Homo sapiens	Q07889	Pull Down	14679214
Intra	SNX9	Q9Y5X1	SOS2	Homo sapiens	Q07890	CoIP	14679214
Intra	SNX9	Q9Y5X1	SOS2	Homo sapiens	Q07890	Pull Down	14679214
Intra	SNX9	Q9Y5X1	UBC	Homo sapiens	P0CG48	Anti Tag CoIP	20491914
Intra	SNX9	Q9Y5X1	WAS	Homo sapiens	P42768	Y2H	17242350
Intra	SNX9	Q9Y5X1	DNM2	Homo sapiens	P50570	Anti Tag CoIP	35271311
Intra	SNX9	Q9Y5X1	DNM2	Homo sapiens	P50570	Anti Tag CoIP	15703209
Intra	SNX9	Q9Y5X1	DNM2	Homo sapiens	P50570	Imaging	15703209
Intra	SNX9	Q9Y5X1	DNM2	Homo sapiens	P50570	BFG-2H	27107012
Intra	SNX9	Q9Y5X1	DNM2	Homo sapiens	P50570	Anti Tag CoIP	33961781
Intra	SNX9	Q9Y5X1	DNM2	Homo sapiens	P50570	Pull Down	18388313
Intra	SNX9	Q9Y5X1	FASLG	Homo sapiens	P48023	Anti Tag CoIP	19807924
Intra	SNX9	Q9Y5X1	FASLG	Homo sapiens	P48023	Phage Display	19807924
Intra	SNX9	Q9Y5X1	OCRL	Homo sapiens	Q01968	Anti Tag CoIP	25107275
Intra	SNX9	Q9Y5X1	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	33961781
Intra	SNX9	Q9Y5X1	DNM1	Homo sapiens	Q05193	Anti Bait CoIP	18353773
Intra	SNX9	Q9Y5X1	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	15703209
Intra	SNX9	Q9Y5X1	DNM1	Homo sapiens	Q05193	Anti Tag CoIP	18353773
Intra	SNX9	Q9Y5X1	ATRAID	Homo sapiens	Q6UW56	Pull Down	18388313
Intra	SNX9	Q9Y5X1	ADAM15	Homo sapiens	Q13444	Filter Binding	16374509
Intra	SNX9	Q9Y5X1	SNX9	Homo sapiens	Q9Y5X1	Solution Sedimentation	18940612
Intra	SNX9	Q9Y5X1	SNX9	Homo sapiens	Q9Y5X1	GMS	18940612
Intra	SNX9	Q9Y5X1	SNX9	Homo sapiens	Q9Y5X1	X-Ray Diffraction	18940612
Intra	SNX9	Q9Y5X1	SNX9	Homo sapiens	Q9Y5X1	SAXS	18940612
Intra	SNX9	Q9Y5X1	WASL	Homo sapiens	O00401	Anti Tag CoIP	18388313
Intra	SNX9	Q9Y5X1	WASL	Homo sapiens	O00401	Pull Down	18388313
Cross	SNX9	Q9Y5X1	espF	Escherichia coli O127:H6	B7UM88	Anti Bait CoIP	16585770
Cross	SNX9	Q9Y5X1	espF	Escherichia coli O127:H6	B7UM88	Y2H	16585770
Cross	SNX9	Q9Y5X1	espF	Escherichia coli O127:H6	B7UM88	Far-WB	16585770
Cross	SNX9	Q9Y5X1	TNK2	Bos taurus	Q17R13	Pull Down	11799118
Cross	SNX9	Q9Y5X1	TNK2	Bos taurus	Q17R13	CoIP	11799118

Cross: Cross-species interaction Intra: Intraspecies interaction

SNX9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82208	SNX9 Antibody (YA1953)	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse
HY-P82208A	SNX9 Antibody (YA1953)(PBS only)	WB, IHC-P, IHC-F, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Trichothiodystrophy 3, Photosensitive	TTD3 Trichothiodystrophy, Complementation Group A Ttda Photosensitive Trichothiodystrophy 3 Trichothiodystrophy Complementation Group A
Lowe Oculocerebrorenal Syndrome	Lowe Syndrome Oculocerebrorenal Syndrome OCRL Oculocerebrorenal Syndrome Of Lowe Ocrl1 Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase Deficiency Lowe Disease Phosphatidylinositol 4,5-Biphosphate 5-Phosphatase Deficiency Cerebrooculorenal Syndrome Phosphatidylinositol-4,5-Bisphosphate-5-Phosphatase Deficiency Lowe Oculo-Cerebro-Renal Dystrophy Lowe Oculo-Cerebro-Renal Syndrome Lowe Oculocerebrorenal Dystrophy Low Chromosome 11p Deletion Syndrome Oculocerebrorenal Dystrophy Cerebro-Oculorenal Dystrophy Ocrl1 - [Oculocerebrorenal Syndrome] Lowe-Terrey-Maclachlan Syndrome Renal-Oculocerebrodystrophy
Coffin-Siris Syndrome 1	Coffin-Siris Syndrome Fifth Digit Syndrome Css CSS1 Mrd12 Mental Retardation, Autosomal Dominant 12 Hhid Dwarfism-Onychodysplasia Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features Autosomal Dominant Mental Retardation 12 Short Stature-Onychodysplasia. Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx Mental Retardation With Hypoplastic Fifth Fingernails And Toenails Short Stature-Onychodysplasia Coffin-Siris Syndrome, Type 1 Mental Retardation, Autosomal Dominant, Type 12
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145307	DATPT		99.91%	Unkown
HY-RS13548	SNX9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19957	Snx9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26459	Snx9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SNX9	MGD	MGI:1913866
Bos taurus	SNX9	VGNC	VGNC:35115
Rattus norvegicus	SNX9	RGD	RGD:1584466
Felis catus	SNX9	VGNC	VGNC:65560
Canis familiaris	SNX9	VGNC	VGNC:46645
Macaca mulatta	SNX9	VGNC	VGNC:77704
Others	SNX9	NCBI