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YOD1 - YOD1 deubiquitinase Gene

Also Known as DUBA8; OTUD2; PRO0907

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55432

About YOD1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:207,043,849-207,053,116 (from NCBI)

This gene has 2 transcripts (splice variants) and 201 orthologues. Broad expression in bone marrow (RPKM 24.5), esophagus (RPKM 15.7) and 23 other tissues.

Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating Enzymes and deubiquitinating Enzymes, adds and removes ubiquitin. Deubiquitinating Enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

YOD1 Products (2)

mRNA	Protein	Name
NM_001276320.2	NP_001263249.1	ubiquitin thioesterase OTU1 isoform 2
NM_018566.4	NP_061036.3	ubiquitin thioesterase OTU1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables K48-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	21376232	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	19818707	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19818707	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24068323	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	19818707	GOA
involved in endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	19818707	GOA
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	27753622	GOA
involved in negative regulation of retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	24068323	GOA
involved in protein K11-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein K11-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	24068323	GOA
involved in protein K27-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein K29-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein K33-linked deubiquitination	IDA IDA: Inferred from direct assay	23827681	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	19818707	GOA
involved in protein K48-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	24068323	GOA
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	19818707	GOA
involved in protein K63-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	24068323	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27753622	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YOD1 Protein Structure

OTU

0
100
200
300
348 a.a.

Protein Preferred Names	Protein Names
ubiquitin thioesterase OTU1	DUBA-8

YOD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	YOD1	Q5VVQ6	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	FAM168A	Homo sapiens	Q92567-2	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	ZFP57	Homo sapiens	Q9NU63-3	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	ZFP57	Homo sapiens	Q9NU63-3	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	ZFP57	Homo sapiens	Q9NU63-3	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	RFC2	Homo sapiens	P35250-2	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	RFC2	Homo sapiens	P35250-2	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	UBXN6	Homo sapiens	Q9BZV1	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	UBXN6	Homo sapiens	Q9BZV1	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	UBXN6	Homo sapiens	Q9BZV1	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	SPART	Homo sapiens	Q8N0X7	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	SPART	Homo sapiens	Q8N0X7	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	SPART	Homo sapiens	Q8N0X7	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	NGRN	Homo sapiens	Q9NPE2	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	NGRN	Homo sapiens	Q9NPE2	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	NGRN	Homo sapiens	Q9NPE2	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	UBC	Homo sapiens	P0CG48	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	UBC	Homo sapiens	P0CG48	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	RNF5	Homo sapiens	Q99942	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	RNF5	Homo sapiens	Q99942	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	RNF5	Homo sapiens	Q99942	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	VCP	Homo sapiens	P55072	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	VCP	Homo sapiens	P55072	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	MKRN1	Homo sapiens	Q9UHC7	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	MKRN1	Homo sapiens	Q9UHC7	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	MKRN1	Homo sapiens	Q9UHC7	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	PLEKHB2	Homo sapiens	Q96CS7	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	PSMA7	Homo sapiens	O14818	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	PSMA7	Homo sapiens	O14818	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	TBX22	Homo sapiens	Q9Y458	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	TBX22	Homo sapiens	Q9Y458	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	TBX22	Homo sapiens	Q9Y458	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	YOD1	Q5VVQ6	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	PLSCR4	Homo sapiens	Q9NRQ2	Y2H Array	32296183
Intra	YOD1	Q5VVQ6	PLSCR4	Homo sapiens	Q9NRQ2	Y2H Prey Pooling	32296183
Intra	YOD1	Q5VVQ6	PLSCR4	Homo sapiens	Q9NRQ2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15930	YOD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20841	Yod1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27355	Yod1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	YOD1	MGD	MGI:2442596
Canis familiaris	YOD1	VGNC	VGNC:48496
Rattus norvegicus	YOD1	RGD	RGD:1359726
Macaca mulatta	YOD1	VGNC	VGNC:79471
Bos taurus	YOD1	VGNC	VGNC:37033
Others	YOD1	NCBI