2. Gene
  3. YOD1 - YOD1 deubiquitinase Gene

YOD1 - YOD1 deubiquitinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as DUBA8; OTUD2; PRO0907

Gene ID: 55432 | Gene type: protein coding

About YOD1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:207,043,849-207,053,116 (from NCBI)

This gene has 2 transcripts (splice variants) and 201 orthologues. Broad expression in bone marrow (RPKM 24.5), esophagus (RPKM 15.7) and 23 other tissues.

Summary

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

YOD1 Products(2)

mRNA Protein Name
NM_001276320.2 NP_001263249.1 ubiquitin thioesterase OTU1 isoform 2
NM_018566.4 NP_061036.3 ubiquitin thioesterase OTU1 isoform 1

YOD1 Protein Structure

OTU

OTU: OTU-like cysteine protease (155 - 254)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
Protein Preferred Names Protein Names

ubiquitin thioesterase OTU1

DUBA-8

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15930 YOD1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus YOD1 MGD MGI:2442596
Canis familiaris YOD1 VGNC VGNC:48496
Rattus norvegicus YOD1 RGD RGD:1359726
Macaca mulatta YOD1 VGNC VGNC:79471
Bos taurus YOD1 VGNC VGNC:37033
Others YOD1 NCBI