STAM - signal transducing adaptor molecule Gene

Also Known as STAM1; STAM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8027

About STAM

Cytogenetic location: 10p12.33 Genomic coordinates (GRCh38): 10:17,644,151-17,716,824 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of Cytokine Receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

STAM Products (9)

mRNA	Protein	Name
NM_001324282.2	NP_001311211.1	signal transducing adapter molecule 1 isoform e
NM_001324283.2	NP_001311212.1	signal transducing adapter molecule 1 isoform c
NM_001324284.2	NP_001311213.1	signal transducing adapter molecule 1 isoform c
NM_001324285.2	NP_001311214.1	signal transducing adapter molecule 1 isoform c
NM_001324286.2	NP_001311215.1	signal transducing adapter molecule 1 isoform d
NM_001324287.2	NP_001311216.1	signal transducing adapter molecule 1 isoform b
NM_001324288.2	NP_001311217.1	signal transducing adapter molecule 1 isoform f
NM_001324289.2	NP_001311218.1	signal transducing adapter molecule 1 isoform f
NM_003473.4	NP_003464.1	signal transducing adapter molecule 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10383417	GOA
enables ubiquitin-like protein ligase binding	IPI IPI: Inferred from physical interaction	24790097	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of exosomal secretion	IMP IMP: Inferred from mutant phenotype	24105262	GOA
involved in regulation of extracellular exosome assembly	IMP IMP: Inferred from mutant phenotype	24105262	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ESCRT-0 complex	IDA IDA: Inferred from direct assay	24790097	GOA
part of ESCRT-0 complex	IPI IPI: Inferred from physical interaction	19278655	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAM Protein Structure

VHS

UIM

SH3_1

0
100
200
300
400
500
540 a.a.

Protein Preferred Names	Protein Names
signal transducing adapter molecule 1	HSE1 homolog

STAM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STAM	Q92783	UBC	Homo sapiens	P0CG48	NMR	12750381
Intra	STAM	Q92783	UBC	Homo sapiens	P0CG48	X-Ray Diffraction	20150893
Intra	STAM	Q92783	LCP2	Homo sapiens	Q13094	Peptide Array	17235283
Intra	STAM	Q92783	STAMBP	Homo sapiens	O95630	Y2H	16730941
Intra	STAM	Q92783	STAMBP	Homo sapiens	O95630	ITC	17078930
Intra	STAM	Q92783	STAMBP	Homo sapiens	O95630	Anti Bait CoIP	10383417
Intra	STAM	Q92783	STAMBP	Homo sapiens	O95630	Pull Down	17078930
Intra	STAM	Q92783	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	10383417
Intra	STAM	Q92783	HGS	Homo sapiens	O14964	Anti Tag CoIP	33961781
Intra	STAM	Q92783	HGS	Homo sapiens	O14964	Y2H Pooling	16189514
Intra	STAM	Q92783	HGS	Homo sapiens	O14964	Anti Tag CoIP	35271311
Cross	STAM	Q92783	UBB	Bos taurus	P0CG53	SPR	20150893

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Charcot-Marie-Tooth Disease, Demyelinating, Type 1c	Charcot-Marie-Tooth Disease Type 1c CMT1C Hmsn1c Hmsn Ic Charcot-Marie-Tooth Disease, Type 1c Charcot-Marie-Tooth Neuropathy Type 1c Cmt, Slow Nerve Conduction Type C Charcot-Marie-Tooth Neuropathy, Type 1c Neuropathy, Hereditary Motor And Sensory, Type Ic Cmt Slow Nerve Conduction Type C Neuropathy Hereditary Motor And Sensory Type 1c Charcot-Marie-Tooth Disease 1c Charcot-Marie-Tooth Disease Demyelinating Type 1c Hereditary Motor And Sensory Neuropathy Ic Charcot-Marie-Tooth Disease, Type Ic
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137922	SHS4121705		/	Unkown
HY-RS13869	STAM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13870	STAM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18974	Stam Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25463	Stam Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STAM	VGNC	VGNC:77902
Felis catus	STAM	VGNC	VGNC:65745
Bos taurus	STAM	VGNC	VGNC:35355
Mus musculus	STAM	MGD	MGI:1329014
Canis familiaris	STAM	VGNC	VGNC:46875
Rattus norvegicus	STAM	RGD	RGD:1564499
Others	STAM	NCBI