ABCG2 - ATP binding cassette subfamily G member 2 (Junior blood group) Gene

Also Known as MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; CDw388; UAQTL1; EST157481

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9429

About ABCG2

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,090,264-88,231,626 (from NCBI)

This gene has 5 transcripts (splice variants), 137 orthologues, 4 paralogues and is associated with 2 phenotypes. Biased expression in small intestine (RPKM 33.2), duodenum (RPKM 16.6) and 12 other tissues.

Summary

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast Cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

ABCG2 Products (16)

mRNA	Protein	Name
XM_011532420.4	XP_011530722.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1
XM_017008852.3	XP_016864341.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X2
NM_001348989.2	NP_001335918.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_001348988.1	NP_001335917.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_001348987.1	NP_001335916.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 3
NM_001257386.2	NP_001244315.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 2
NM_001348986.1	NP_001335915.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_001348985.1	NP_001335914.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_004827.3	NP_004818.2	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_001257386.2	NP_001244315.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 2
NM_001348985.1	NP_001335914.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_001348986.1	NP_001335915.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_001348987.1	NP_001335916.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 3
NM_001348988.1	NP_001335917.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_001348989.2	NP_001335918.1	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1
NM_004827.3	NP_004818.2	broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ABC-type xenobiotic transporter activity	IDA IDA: Inferred from direct assay	9861027	GOA
enables ATPase-coupled transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	28554189	GOA
enables efflux transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	17145775	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16870176	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18056989	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	16870176	GOA
enables riboflavin transmembrane transporter activity	IDA IDA: Inferred from direct assay	17145775	GOA
enables urate transmembrane transporter activity	IDA IDA: Inferred from direct assay	36749388	GOA
enables urate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	19506252	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular detoxification	IDA IDA: Inferred from direct assay	9861027	GOA
involved in renal urate salt excretion	IMP IMP: Inferred from mutant phenotype	19506252	GOA
involved in riboflavin transport	IDA IDA: Inferred from direct assay	17145775	GOA
involved in transepithelial transport	IDA IDA: Inferred from direct assay	12958161	GOA
involved in transmembrane transport	IMP IMP: Inferred from mutant phenotype	28554189	GOA
involved in urate metabolic process	IMP IMP: Inferred from mutant phenotype	18834626	GOA
involved in xenobiotic transport across blood-brain barrier	IDA IDA: Inferred from direct assay	12958161	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in brush border membrane	IDA IDA: Inferred from direct assay	19506252	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	28623970	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18619525	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCG2 Protein Structure

ABC_tran

ABC2_membrane

0
200
400
600
655 a.a.

Protein Preferred Names	Protein Names
broad substrate specificity ATP-binding cassette transporter ABCG2	ABC transporter ATP-binding cassette transporter G2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) breast cancer resistance protein broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1 (Junior blood group) mitoxantrone resistance-associated protein multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 placenta specific MDR protein placenta-specific ATP-binding cassette transporter urate exporter

ABCG2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ABCG2	Q9UNQ0	PIM1	Homo sapiens	P11309-2	Anti Tag CoIP	18056989
Intra	ABCG2	Q9UNQ0	PIM1	Homo sapiens	P11309-2	Y2H	18056989
Intra	ABCG2	Q9UNQ0	TRIM13	Homo sapiens	O60858	Anti Tag CoIP	33961781
Intra	ABCG2	Q9UNQ0	ABCG2	Homo sapiens	Q9UNQ0	Comig Non-Denat Gel	19506252
Intra	ABCG2	Q9UNQ0	ABCG2	Homo sapiens	Q9UNQ0	Anti Tag CoIP	16870176
Intra	ABCG2	Q9UNQ0	ABCG2	Homo sapiens	Q9UNQ0	3D-EM	17098188
Intra	ABCG2	Q9UNQ0	ABCG2	Homo sapiens	Q9UNQ0	BN-PAGE	17098188
Intra	ABCG2	Q9UNQ0	ATP5F1B	Homo sapiens	P06576	Anti Tag CoIP	33961781
Intra	ABCG2	Q9UNQ0	ENPP1	Homo sapiens	P22413	Pull Down	26065921
Intra	ABCG2	Q9UNQ0	LGALS3	Homo sapiens	P17931	Anti Tag CoIP	33961781
Intra	ABCG2	Q9UNQ0	UBC	Homo sapiens	P0CG48	Anti Bait CoIP	19909340
Intra	ABCG2	Q9UNQ0	ABCG2	Homo sapiens	Q9UNQ0	EM	20399185
Intra	ABCG2	Q9UNQ0	SCAMP1	Homo sapiens	O15126	Anti Tag CoIP	33961781
Intra	ABCG2	Q9UNQ0	CLPP	Homo sapiens	Q16740	Anti Tag CoIP	33961781
Intra	ABCG2	Q9UNQ0	ENPP1	Homo sapiens	P22413	Anti Tag CoIP	26065921

Cross: Cross-species interaction Intra: Intraspecies interaction

ABCG2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80002	ABCG2 Antibody (YA648)	WB, ICC/IF, IHC-P, FC	Human, Mouse
HY-P84881	ABCG2 Antibody (YA4578)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P84881A	ABCG2 Antibody (YA4578)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey

Related Diseases

Diseases	Alias
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Sitosterolemia	Phytosterolemia Beta-Sitosterolemia Plant Sterol Storage Disease Phytosterolæmia Sitosterolæmia Retention Of Dietary Cholesterol And Abnormal Retention Of Non-Cholesterol Sterols In The Body Phytosterolaemia Sitosterolaemia Sitosterolemia With Xanthomatosis
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Lung Non-Squamous Non-Small Cell Carcinoma	Non- Squamous Nsclc
Placental Choriocarcinoma	Choriocarcinoma Of The Placenta
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Multiple Benign Circumferential Skin Creases On Limbs	Ccsf Circumferential Skin Creases, Kunze Type Congenital Circumferential Skin Folds Kunze-Riehm Syndrome Kunze Riehm Syndrome Michelin Tire Baby Syndrome
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Rhabdomyosarcoma
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Blood Group, Junior System	JR Junior Blood Group System Blood Group System, Junior
Neutropenia	Leukopenia
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Dubin-Johnson Syndrome	DJS Chronic Idiopathic Jaundice Jaundice, Chronic Idiopathic Hyperbilirubinemia, Dubin-Johnson Type Hyperbilirubinemia Ii Hyperbilirubinemia Type 2 Conjugated Hyperbilirubinemia Dubin-Sprinz Disease Sprinz-Nelson Syndrome Hblrdj Dubin Johnson Syndrome Hyperbilirubinemia 2 Black Liver-Jaundice Syndrome Chronic Idiopathic Jaundice With Pigmented Liver Dubin-Sprinz Syndrome Hyperbilirubinaemia Type 2 Djs - [Dubin-Johnson Syndrome]
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ocular Cancer	Eye Carcinoma Eye Neoplasm Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Choriocarcinoma	Chorioepithelioma
Uric Acid Concentration, Serum, Quantitative Trait Locus 1	UAQTL1 Gout Susceptibility 1 Gout1 Uric Acid Concentration, Serum, Qtl1
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Gestational Choriocarcinoma	Gestational Chorionepithelioma Molar Pregnancy With Choriocarcinoma
Persistent Fetal Circulation Syndrome	Fetal Circulation Persistent Fetal Circulation Persistent Pulmonary Hypertension Of The Newborn Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins Persistent Foetal Circulation Persistent Foetal Circulation Syndrome Pfc - [Persistent Fetal Circulation] Syndrome Pphn - [Persistent Pulmonary Hypertension Of The Newborn] Newborn Pulmonary Hypertension Primary Pulmonary Hypertension Of Newborn
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Hyperuricemia	Blood Urate Raized Uricacidemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10440	Vismodegib		99.97%	Yes
HY-101561	Avapritinib	Inhibitor	99.85%	Yes
HY-109061	Lazertinib		99.87%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109019	Vorolanib	Inhibitor	99.78%	Phase 3
HY-101570	Nedisertib		99.70%	Phase 2
HY-10527C	Telatinib mesylate	Inhibitor	99.74%	Phase 2

Pre-clinical Phase

Bioactive Molecules (59)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10010	Ko 143	Inhibitor	99.97%	Unkown
HY-11079	A-803467	Inhibitor	99.69%	Unkown
HY-N2143	Fumitremorgin C	Inhibitor	99.92%	Unkown
HY-101453	Ceefourin 1	Inhibitor	99.72%	Unkown
HY-10873	N-Desethyl Sunitinib		99.81%	Unkown
HY-12757	YHO-13177	Inhibitor	99.65%	Unkown
HY-D2869	Ac-H-FluNox		99.88%	Unkown
HY-109061B	Lazertinib mesylate		99.85%	Unkown
HY-12758	YHO-13351	Inhibitor	99.16%	Unkown
HY-136450	Triclabendazole sulfoxide	Inhibitor	98.34%	Unkown
HY-18010	PCI 29732	Inhibitor	99.59%	Unkown
HY-111678	ML230	Inhibitor	99.65%	Unkown
HY-100933	MY-5445	Inhibitor	99.79%	Unkown
HY-113805	MC70	Inhibitor	99.50%	Unkown
HY-144305	KPH2f	Inhibitor	99.22%	Unkown
HY-112505	Efflux inhibitor-1	Inhibitor	98.0%	Unkown
HY-151432	URAT1 inhibitor 3	Inhibitor	98.02%	Unkown
HY-P5391	LL-37(17-32)	Inhibitor	96.71%	Unkown
HY-RS00077	ABCG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W049875	Nitroxynil		98.92%	Unkown
HY-183623	ProAlk01	Inducer	/	Unkown
HY-101570G	Nedisertib (GMP)	Inhibitor	/	Unkown
HY-109061A	Lazertinib mesylate hydrate		/	Unkown
HY-118083	Pentamethoxymorin	Inhibitor	/	Unkown
HY-121645	2,4-Dibromoestradiol		/	Unkown
HY-122416	6,8-Diprenylnaringenin	Inhibitor	/	Unkown
HY-129301	CCTA-1523	Inhibitor	/	Unkown
HY-136450S	Triclabendazole sulfoxide-d3	Inhibitor	/	Unkown
HY-136450S1	Triclabendazole sulfoxide-13C,d3	Inhibitor	/	Unkown
HY-13774	WK-X-34	Inhibitor	/	Unkown
HY-146676	UR-MB108	Inhibitor	/	Unkown
HY-155652	ABCG2-IN-1	Inhibitor	/	Unkown
HY-155653	ABCG2-IN-2	Inhibitor	/	Unkown
HY-156092	Antitumor photosensitizer-4		/	Unkown
HY-168573	AZ99	Inhibitor	/	Unkown
HY-170396	ABCG2-IN-4	Inhibitor	/	Unkown
HY-174435	ABCB1/ABCG2-IN-1	Inhibitor	/	Unkown
HY-17648	MBL-II-141	Inhibitor	/	Unkown
HY-178100	PARP1-IN-45	Inhibitor	/	Unkown
HY-178386	ABCG2-IN-5	Inhibitor	/	Unkown
HY-181731S	(R,S,R)-Altenuene-13C15		/	Unkown
HY-181802	MRS8431		/	Unkown
HY-181803	MRS8432		/	Unkown
HY-181804	MRS8288	Inhibitor	/	Unkown
HY-182000	Xanthine oxidase-IN-23		/	Unkown
HY-D3179	CDg13	Substrate	/	Unkown
HY-RS00078	Abcg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00079	Abcg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W082856A	Butein tetramethyl ether	Inhibitor	/	Unkown
HY-119724	ABCG2-IN-3	Inhibitor	/	Unkown
HY-123526	NSC265473		/	Unkown
HY-136450R	Triclabendazole sulfoxide (Standard)	Inhibitor	/	Unkown
HY-149469	3,7,2',4'-Tetramethoxy-5-hydroxyflavone	Inhibitor	/	Unkown
HY-168572	MZ82	Inhibitor	/	Unkown
HY-N2651	5,7,3'-Trihydroxy-4'-Methoxy-8-prenylflavanone	Inhibitor	/	Unkown
HY-W705354	Vismodegib-d4		/	Unkown
HY-W716916	Vismodegib-d7		/	Unkown
HY-W754911	Avapritinib-d3	Inhibitor	/	Unkown
HY-W843469	1-Hydroxyacridin-9(10H)-one	Control	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ABCG2	VGNC	VGNC:53683
Macaca mulatta	ABCG2	VGNC	VGNC:100198
Canis familiaris	ABCG2	VGNC	VGNC:49113
Mus musculus	ABCG2	MGD	MGI:1347061
Felis catus	ABCG2	VGNC	VGNC:78447
Rattus norvegicus	ABCG2	RGD	RGD:631345
Others	ABCG2	NCBI