1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

Lazertinib (Synonyms: YH25448; GNS-1480)

Cat. No.: HY-109061 Purity: 98.00%
Handling Instructions

Lazertinib is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer.

For research use only. We do not sell to patients.

Lazertinib Chemical Structure

Lazertinib Chemical Structure

CAS No. : 1903008-80-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 268 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Lazertinib is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer.

IC50 & Target[1]

EGFRT790M

 

In Vitro

Lazertinib (YH25448) is a potent, highly mutant-selective, blood-brain barrier permeable, orally available and irreversible third-generation EGFR tyrosine kinase inhibitor, and can be used in the research of non-small cell lung cancer. Lazertinib targets both T790M mutation and activating EGFR mutations (EGFRm) while sparing wild type[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (45.07 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8030 mL 9.0149 mL 18.0297 mL
5 mM 0.3606 mL 1.8030 mL 3.6059 mL
10 mM 0.1803 mL 0.9015 mL 1.8030 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

554.64

Formula

C₃₀H₃₄N₈O₃

CAS No.

1903008-80-9

SMILES

C=CC(NC1=CC(NC2=NC=CC(N3N=C(C4=CC=CC=C4)C(CN(C)C)=C3)=N2)=C(OC)C=C1N5CCOCC5)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Lazertinib
Cat. No.:
HY-109061
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Lazertinib

Cat. No.: HY-109061