2. Membrane Transporter/Ion Channel
  3. BCRP
  4. Pentamethoxymorin

Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer.

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Pentamethoxymorin

Pentamethoxymorin Chemical Structure

CAS No. : 7555-80-8

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Pentamethoxymorin Related Antibodies

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Description

Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer[1].

In Vitro

Pentamethoxymorin (compound 11) (0.031-100 µM; 30 min-72 h) inhibits BCRP and weakly inhibits P-gp, with no MRP1 inhibition and low cytotoxicity (IC50 = 5.94-5.98 μM for BCRP, 27.1 μM for P-gp)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pentamethoxymorin Related Antibodies
Molecular Weight

372.37

Formula

C20H20O7
CAS No.
SMILES

O=C1C(OC)=C(OC2=CC(OC)=CC(OC)=C21)C=3C=CC(OC)=CC3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pentamethoxymorin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pentamethoxymorin7555-80-8MRS923MRS 923MRS-923BCRPBreast cancer resistance proteinABCG2P-gp-overexpressing cellsBCRP/ABCG2P-gpMRP1Breast Cancer Resistance ProteinBCRP substratesP-glycoproteinBCRP-expressing cellsMultidrug resistance-associated protein 1MRP1-overexpressing cellsInhibitorinhibitorinhibit

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