7555-80-8
Chemical Structure
Pentamethoxymorin
Synonym(s): MRS923
- CAS No.: 7555-80-8
- Formula:C20H20O7
- Molecular Weight:372.37
IUPAC Name: 2-(2,4-dimethoxyphenyl)-3,5,7-trimethoxy-4H-chromen-4-one
InChIKey: KPJGABLCRGWDRB-UHFFFAOYSA-N
SMILES: O=C1C(OC)=C(OC2=CC(OC)=CC(OC)=C21)C=3C=CC(OC)=CC3OC
Biological Activity: Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer[1].
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Pentamethoxymorin | Pentamethoxymorin (MRS923) is a selective breast cancer resistance protein (BCRP/ABCG2) inhibitor. Pentamethoxymorin shows selectivity for BCRP over P-gp and MRP1. Pentamethoxymorin inhibits MDCK BCRP cells with IC50 vaues of 5.98 μM and 5.94 μM in Hoechst 33342 (HY-15559) assay and Pheophorbide A (HY-125665) assay, respectively. Pentamethoxymorin can be used for the study of ccancer. | |||||||||||||||||||||
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Keywords
