1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK
  3. Ulixertinib hydrochloride

Ulixertinib hydrochloride (Synonyms: BVD-523 hydrochloride; VRT752271 hydrochloride)

Cat. No.: HY-15816A Purity: 99.89%
Handling Instructions

Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line.

For research use only. We do not sell to patients.

Ulixertinib hydrochloride Chemical Structure

Ulixertinib hydrochloride Chemical Structure

CAS No. : 1956366-10-1

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Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 85 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 77 In-stock
Estimated Time of Arrival: December 31
10 mg USD 121 In-stock
Estimated Time of Arrival: December 31
50 mg USD 275 In-stock
Estimated Time of Arrival: December 31
100 mg USD 495 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of Ulixertinib hydrochloride:

Top Publications Citing Use of Products

    Ulixertinib hydrochloride purchased from MCE. Usage Cited in: Innate Immun. 2020 Aug;26(6):505-513.

    The protein levels of p-ERK1/2, ERK1/2, p-RSK, and RSK are measured by Western blotting.

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    • Biological Activity

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    Description

    Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. Ulixertinib hydrochloride inhibits the phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) in an A375 melanoma cell line[1][2].

    In Vitro

    Combined Ulixertinib (BVD-523; 10, 20, 30 μM; 48 hours) and VS-5584 treatment causes significant induction of cell death in human pancreatic cancer (HPAC) cells in PDAC cell lines BxPC-3, MIAPaCa-2, and CFPAC-1[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    469.79

    Formula

    C21H23Cl3N4O2

    CAS No.
    SMILES

    O=C(C1=CC(C2=CC(NC(C)C)=NC=C2Cl)=CN1)N[[email protected]@H](C3=CC=CC(Cl)=C3)CO.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (212.86 mM; Need ultrasonic)

    H2O : 0.1 mg/mL (0.21 mM; ultrasonic and warming and heat to 80°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1286 mL 10.6431 mL 21.2861 mL
    5 mM 0.4257 mL 2.1286 mL 4.2572 mL
    10 mM 0.2129 mL 1.0643 mL 2.1286 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (4.43 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.43 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.43 mM); Clear solution

    *All of the co-solvents are available by MCE.
    References

    Purity: 99.89%

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    Product Name:
    Ulixertinib hydrochloride
    Cat. No.:
    HY-15816A
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