1. MAPK/ERK Pathway
    Stem Cell/Wnt
  2. ERK

MK-8353 (Synonyms: SCH900353)

Cat. No.: HY-111407
Handling Instructions

MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.

For research use only. We do not sell to patients.

MK-8353 Chemical Structure

MK-8353 Chemical Structure

CAS No. : 1184173-73-6

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Description

MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity.

IC50 & Target[1]

ERK2

8.8 nM (IC50)

ERK1

23 nM (IC50)

In Vitro

MK-8353 is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. MK-8353 only at 1 μM shows >50% inhibition on 3 kinases (CLK2, FLT4, and Aurora B), and no other kinases tested are inhibited by >35% at 0.1 μM. MK-8353 also shows potent antitumor activity against various cancer cell lines, such Malme-3M cells (Melanoma), Colo-205 cells (Colon), NCI-H292 cells (Lung), A-549 cells (NSCLC), 8505C cells (Thyroid), SW-626 cells (Ovarian), with EC50s of 21 nM, 19 nM, 130 nM, 230 nM, 210 nM, 108 nM[1].

In Vivo

MK-8353 (60 mg/kg, p.o., bid (twice daily)) causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells, including LOX, Colo-205, MIA PaCa-2, and Calu-6 cells[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4454 mL 7.2271 mL 14.4542 mL
5 mM 0.2891 mL 1.4454 mL 2.8908 mL
10 mM 0.1445 mL 0.7227 mL 1.4454 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

691.84

Formula

C₃₇H₄₁N₉O₃S

CAS No.

1184173-73-6

SMILES

O=C([[email protected]@]1(SC)CN(CC(N2CC=C(C3=CC=C(C4=NN(C)C=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=C(OC(C)C)N=C7)C=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MK-8353
Cat. No.:
HY-111407
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MK-8353

Cat. No.: HY-111407