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Cat. No.: HY-111407A

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MK-8353 hydrochloride

(Synonyms: SCH900353 hydrochloride; MK-8353-001)

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

MK-8353 (SCH900353) hydrochloride is a potent, selective, orally active ERK1/2 inhibitor with IC₅₀ values of 23.0 nM and 8.8 nM, respectively. MK-8353 exhibits antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 1951448-73-9
Formula: C₃₇H₄₂ClN₉O₃S
Molecular Weight:728.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

MK-8353 hydrochloride Chemical Structure

CAS No.: 1951448-73-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Clinical Trial
Chemical Information
Publications (5)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MK-8353 (SCH900353) hydrochloride is a potent, selective, orally active ERK1/2 inhibitor with IC₅₀ values of 23.0 nM and 8.8 nM, respectively. MK-8353 exhibits antitumor activity^[1].

IC₅₀ & Target^[1]

ERK1

23 nM (IC₅₀)

ERK2

8.8 nM (IC₅₀)

All ERK Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1951448-73-9
Molecular Weight 728.31
Formula C₃₇H₄₂ClN₉O₃S
SMILES

O=C([C@@]1(SC)CN(CC(N2CC=C(C3=CC=C(C4=NN(C)C=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=C(OC(C)C)N=C7)C=C5.Cl
Synonyms

SCH900353 hydrochloride; MK-8353-001
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Journal Impact Factor

Nat Nanotechnol

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. [Abstract]

2021 Jul;16(7):830-839. PMID: 33958764
J Nanobiotechnology

Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development. [Abstract]

2025 Jul 18;23(1):524. PMID: 40682120
Cell Rep

Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma. [Abstract]

2024 Dec 3;43(12):115026. PMID: 39630579
Mol Med Rep

S100A1 expression is increased in spinal cord injury and promotes inflammation, oxidative stress and apoptosis of PC12 cells induced by LPS via ERK signaling. [Abstract]

2023 Feb;27(2):30. PMID: 36524376

MK-8353 hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2023 Feb;27(2):30. [Abstract]

MK‑8353 partially counteractes the inhibitory effects of S100A1 overexpression on Nrf2 level in PC12 cells.
State University of New York at Stony Brook

2025.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Moschos SJ, et al. Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors. JCI Insight. 2018 Feb 22;3(4). pii: 92352. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MK-8353 hydrochloride

5 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
- Clinical Trial
Chemical Information
Publications (5)
Purity & Documentation
References

1/16
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MK-8353 hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2023 Feb;27(2):30. [Abstract]

Customer Validation
MK‑8353 partially counteractes the inhibitory effects of S100A1 overexpression on Nrf2 level in PC12 cells.

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MK-8353 hydrochloride

Publications Citing Use of MedChemExpress (MCE) MK-8353 hydrochloride

All ERK Isoforms

Biological Activity

Chemical Information

Publications (5)

Purity & Documentation

References

Calculators

Help & FAQs

MK-8353 hydrochloride Related Classifications

HY-111407A Related Classifications