1951448-73-9
Chemical Structure
MK-8353 hydrochloride
Synonym(s): SCH900353 hydrochloride; MK-8353-001
- CAS No.: 1951448-73-9
- Formula:C37H42ClN9O3S
- Molecular Weight:728.31
IUPAC Name: (S)-N-(3-(6-isopropoxypyridin-3-yl)-1H-indazol-5-yl)-1-(2-(4-(4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)-2-oxoethyl)-3-(methylthio)pyrrolidine-3-carboxamide hydrochloride
InChIKey: MAEYDGFPLZDKHE-JFRIYMKVSA-N
SMILES: O=C([C@@]1(SC)CN(CC(N2CC=C(C3=CC=C(C4=NN(C)C=N4)C=C3)CC2)=O)CC1)NC5=CC6=C(NN=C6C7=CC=C(OC(C)C)N=C7)C=C5.Cl
Biological Activity: MK-8353 (SCH900353) hydrochloride is a potent, selective, orally active ERK1/2 inhibitor with IC50 values of 23.0 nM and 8.8 nM, respectively. MK-8353 exhibits antitumor activity[1].
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MK-8353 hydrochloride | MK-8353 (SCH900353) hydrochloride is a potent, selective, orally active ERK1/2 inhibitor with IC50 values of 23.0 nM and 8.8 nM, respectively. MK-8353 exhibits antitumor activity. | |||||||||||||||||||||
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