TRIM13 - tripartite motif containing 13 Gene

Also Known as CAR; LEU5; RFP2; DLEU5; RNF77

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10206

About TRIM13

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,997,042-50,018,467 (from NCBI)

This gene has 8 transcripts (splice variants), 211 orthologues and 80 paralogues. Broad expression in testis (RPKM 17.7), bone marrow (RPKM 8.8) and 25 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

TRIM13 Products (4)

mRNA	Protein	Name
NM_001007278.3	NP_001007279.1	E3 ubiquitin-protein ligase TRIM13 isoform 2
NM_005798.5	NP_005789.2	E3 ubiquitin-protein ligase TRIM13 isoform 1
NM_052811.4	NP_434698.1	E3 ubiquitin-protein ligase TRIM13 isoform 1
NM_213590.3	NP_998755.1	E3 ubiquitin-protein ligase TRIM13 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17314412	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	23077300	GOA
enables ubiquitin-like protein ligase activity	IDA IDA: Inferred from direct assay	21333377	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	17314412	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	17314412	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18248090	GOA
involved in negative regulation of viral transcription	IDA IDA: Inferred from direct assay	18248090	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23077300	GOA
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	22178386	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	17314412	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	17314412	GOA
involved in suppression of viral release by host	IDA IDA: Inferred from direct assay	18248090	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11331580	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17314412	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	17314412	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM13 Protein Structure

zf-RING_2

zf-B_box

0
100
200
300
407 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM13	B-cell chronic lymphocytic leukemia tumor suppressor Leu5

TRIM13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRIM13	O60858	FLJ13057	Homo sapiens	Q53SE7	Y2H Array	25416956
Intra	TRIM13	O60858	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Psoriasis 11	PSORS11 Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Psoriasis 11, Susceptibility To Pv
Adrenal Gland Pheochromocytoma	Pheochromocytoma
Pain Agnosia	Analgesia
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Late-Onset Retinal Degeneration	LORD Retinal Degeneration, Late-Onset, Autosomal Dominant Autosomal Dominant Late-Onset Retinal Degeneration Pigmentary Retinopathy Retinal Degeneration, Late-Onset Retinitis Pigmentosa

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15021	TRIM13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21958	Trim13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28475	Trim13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRIM13	VGNC	VGNC:47805
Rattus norvegicus	TRIM13	RGD	RGD:1307609
Felis catus	TRIM13	VGNC	VGNC:69301
Bos taurus	TRIM13	VGNC	VGNC:36314
Mus musculus	TRIM13	MGD	MGI:1913847
Macaca mulatta	TRIM13	VGNC	VGNC:79972
Others	TRIM13	NCBI