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Cat. No.: HY-129301

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CCTA-1523

CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity.

For research use only. We do not sell to patients.

CAS No.: 1616271-41-0
Formula: C₁₆H₁₅Cl₂NO₃
Molecular Weight:340.20

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CCTA-1523 Chemical Structure

CAS No.: 1616271-41-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity^[1].

In Vitro

CCTA-1523 (0-1000 µM; 72 h) shows cytotoxicity for H460, H460/MX20, HEK293/pcDNA3.1, HEK/R482, HEK/R482G and HEK/R482T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CCTA-1523 (75 mg/kg; p.o.; q3d x 6) combined with doxorubicin (HY-15142A) (1.8 mg/kg, i.p., q3d X 6) inhibits tumor growth and increases the survival time in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NCR nude mice (H460/MX20 xenografts)^[1]
Dosage:

75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
Administration:

P.o.;q3d x 6
Result:

Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.

Chemical Information

CAS No. 1616271-41-0
Molecular Weight 340.20
Formula C₁₆H₁₅Cl₂NO₃
SMILES

O=C(C(Cl)Cl)NC1=CC(C2=CC=C(C(OC)=C2)OC)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Patel A,et al. Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport. Pharmacol Res. 2017 Jul;121:184-193. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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