Butein tetramethyl ether
Butein tetramethyl ether (Compound 20) is a potent and selective breast cancer resistance protein/ATP-binding cassette subfamily G member 2 (BCRP/ABCG2) inhibitor. Butein tetramethyl ether has inhibitory potencies against MCF-7 MX and MDCK BCRP cells with IC50 values of 2.2 and 1.03 μM, respectively. Butein tetramethyl ether is promising for research of cancers.
For research use only. We do not sell to patients.
- CAS No.: 155048-06-9
- Formula: C19H20O5
- Molecular Weight:328.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDCK-II | IC50 |
1.03 μM
Compound: 20
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Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry
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[PMID: 22112540] |
Chemical Information
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CAS No. 155048-06-9
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Molecular Weight 328.36
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Formula C19H20O5
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SMILES
COC(C=C1/C=C/C(C2=C(C=C(C=C2)OC)OC)=O)=C(C=C1)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Butein tetramethyl ether Related Classifications
HY-W082856A Related Classifications
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