1. Membrane Transporter/Ion Channel
  2. BCRP
  3. ML230

ML230 (Synonyms: CID44640177; SID 88095709)

Cat. No.: HY-111678 Purity: 99.12%
Handling Instructions

ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2, and 36-fold selective for ABCG2 over ABCB1 with EC50s values of 0.13 μM and 4.65 μM, respectively.

For research use only. We do not sell to patients.

ML230 Chemical Structure

ML230 Chemical Structure

CAS No. : 1776055-05-0

Size Price Stock Quantity
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2, and 36-fold selective for ABCG2 over ABCB1 with EC50s values of 0.13 μM and 4.65 μM, respectively[1].

IC50 & Target

EC50: ABCG2 (0.13 μM)[1]

Molecular Weight

439.47

Formula

C25H21N5O3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (75.84 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2755 mL 11.3773 mL 22.7547 mL
5 mM 0.4551 mL 2.2755 mL 4.5509 mL
10 mM 0.2275 mL 1.1377 mL 2.2755 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.69 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.12%

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ML230
Cat. No.:
HY-111678
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