1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. MY-5445

MY-5445 

Cat. No.: HY-100933 Purity: 99.79%
Handling Instructions

MY-5445 est un inhibiteur spécifique de la phosphodiestérase de type 5 (PDE5). MY-5445 inhibe sélectivement PDE cGMP avec un Ki de 1,3 μM.

MY-5445 is a specific inhibitor of the cyclic GMP phosphodiesterase, phosphodiesterase type 5 (PDE5), with a Ki of 1.3 μM. MY-5445 inhibits human platelet aggregation. MY-5445 is a selective modulator of ATP-binding cassette (ABC) transporter ABCG2, with anti-proliferative effect.

For research use only. We do not sell to patients.

MY-5445 Chemical Structure

MY-5445 Chemical Structure

CAS No. : 78351-75-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

MY-5445 is a specific inhibitor of the cyclic GMP phosphodiesterase, phosphodiesterase type 5 (PDE5), with a Ki of 1.3 μM. MY-5445 inhibits human platelet aggregation. MY-5445 is a selective modulator of ATP-binding cassette (ABC) transporter ABCG2, with anti-proliferative effect[1][2].

IC50 & Target[1][3]

PDE5

1.3 μM (Ki)

PDE5

6.7 μM (IC50)

PDE4

37 μM (IC50)

In Vitro

MY-5445 inhibits human platelet aggregation by increasing cyclic GMP content and that it provides a useful probe for elucidating the role of cyclic GMP in platelet aggregation [1].
MY-5445 selectively reverses ABCG2-mediated multidrug resistance in ABCG2-overexpressing cells[2].
MY-5445 reverses ABCG2-mediated multidrug resistance (MDR) by potentiating the cytotoxicity of an ABCG2 substrate drug in ABCG2-overexpressing multidrug-resistant cancer cells, possibly by modulating the function and/or the protein expression of ABCG2[2].
MY-5445 (3 μM; 48 hours) substantially increases the topotecan-induced apoptosis in S1-M1-80 cell[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Human S1 colon cancer cells, S1-M1-80 cancer cells
Concentration: 3 μM
Incubation Time: 48 hours
Result: Enhanced drug-induced apoptosis in ABCG2-overexpressing cancer cells.
In Vivo

MY-5445 (0.5-3 mg/kg; i.p.; twice a day; for 15 days) produces a significant relief of mechanical hypersensitivity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male mice[3]
Dosage: 0.5 mg/kg, 3 mg/kg
Administration: Intraperitoneal injection, twice a day, for 15 days
Result: Alleviated the cuff-induced allodynia.
Molecular Weight

331.80

Formula

C₂₀H₁₄ClN₃

CAS No.

78351-75-4

SMILES

ClC1=CC(NC2=NN=C(C3=CC=CC=C3)C4=C2C=CC=C4)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (150.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0139 mL 15.0693 mL 30.1386 mL
5 mM 0.6028 mL 3.0139 mL 6.0277 mL
10 mM 0.3014 mL 1.5069 mL 3.0139 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.53 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.79%

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Keywords:

MY-5445MY5445MY 5445Phosphodiesterase (PDE)plateletaggregationanticancerneuropathic painneuropathicallodyniaInhibitorinhibitorinhibit

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Product Name:
MY-5445
Cat. No.:
HY-100933
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