1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

Cilostamide (Synonyms: OPC3689)

Cat. No.: HY-101312 Purity: 99.63%
Handling Instructions

Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.

For research use only. We do not sell to patients.

Cilostamide Chemical Structure

Cilostamide Chemical Structure

CAS No. : 68550-75-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
25 mg USD 230 In-stock
Estimated Time of Arrival: December 31
50 mg USD 410 In-stock
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100 mg USD 730 In-stock
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500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.

IC50 & Target

IC50: 27 nM (PDE3A), 50 nM (PDE3B)[1]

In Vitro

Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity. Cilostamide weakly inhibits PDE2, PDE4, PDE5, PDE7, and PDE1, with IC50s of 12.5, 88.8, 15.2, 22.0 and > 300 μM, respectively. Cilostamide potently inhibits thrombin-induced platelet aggregation (IC50, 1.1 μM)[1].

Solvent & Solubility
In Vitro: 

DMSO : 31 mg/mL (90.53 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9203 mL 14.6015 mL 29.2030 mL
5 mM 0.5841 mL 2.9203 mL 5.8406 mL
10 mM 0.2920 mL 1.4602 mL 2.9203 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Platelet aggregation is investigated in the assay. Washed platelets (200 μL of a suspension containing 3 × 108 cells/mL in Tyrode HEPES buffer, pH 7.4) are incubated for 3 min at 37°C in the presence or absence of different concentrations of OPC-33540, OPC-33536, and Cilostamide alone, or in combination with 3 nM PGE1, followed by incubation with 5 μL of 2 units/mL of thrombin for 5 min at 37°C. The intensity of light transmitted over 5 min is measured using a PAM-8C aggregometer. The inhibition rate is calculated by comparison of maximum aggregation rates with the control value[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

342.43

Formula

C₂₀H₂₆N₂O₃

CAS No.

68550-75-4

SMILES

O=C(N(C1CCCCC1)C)CCCOC2=CC3=C(NC(C=C3)=O)C=C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Product Name:
Cilostamide
Cat. No.:
HY-101312
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Cilostamide

Cat. No.: HY-101312