1. Protein Tyrosine Kinase/RTK
  2. Btk

PCI 29732 

Cat. No.: HY-18010
Handling Instructions

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.

For research use only. We do not sell to patients.

PCI 29732 Chemical Structure

PCI 29732 Chemical Structure

CAS No. : 330786-25-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
50 mg USD 864 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1560 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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    PCI 29732 purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2018;48(6):2302-2317.

    Effects of PCI29732 on total and phosphorylated levels of AKT and ERK1/2. S1-MI-80 cells are treated with various concentrations (0-3 μM) of PCI29732 for 48 h, or with 1.5 μM of PCI29732 for 24, 48, or 72 h.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. IC50 value: 8.2 nM [1] Target: Btk kinase PCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1]. In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2].

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 53 mg/mL (142.69 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6922 mL 13.4611 mL 26.9222 mL
    5 mM 0.5384 mL 2.6922 mL 5.3844 mL
    10 mM 0.2692 mL 1.3461 mL 2.6922 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    371.44

    Formula

    C₂₂H₂₁N₅O

    CAS No.

    330786-25-9

    SMILES

    NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2C5CCCC5

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    PCI 29732
    Cat. No.:
    HY-18010
    Quantity:

    PCI 29732

    Cat. No.: HY-18010