3,7,2',4'-Tetramethoxy-5-hydroxyflavone
BCRP/ABCG2-IN-1 is the inhibitor of breast cancer resistance protein (BCRP/ABCG2), with IC50 of 5.98 μM, that can be used in multidrug resistance of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 19056-75-8
- Formula: C19H18O7
- Molecular Weight:358.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MDCK-II | IC50 |
3.27 μM
Compound: 13
|
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of Hoechst 33342 preincubated for 30 mins before Hoechst 33342 addition measured after 120 mins by fluorescence assay
|
[PMID: 23851114] |
| MDCK-II | IC50 |
3.89 μM
Compound: 13
|
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
Inhibition of human BCRP expressed in MDCK2 cells assessed as accumulation of pheophorbide-A preincubated for 30 mins before pheophorbide-A addition measured after 120 mins by flow cytometry
|
[PMID: 23851114] |
Chemical Information
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CAS No. 19056-75-8
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Molecular Weight 358.34
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Formula C19H18O7
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SMILES
O=C1C(OC)=C(C2=C(OC)C=C(OC)C=C2)OC3=C1C(O)=CC(OC)=C3
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)