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Cat. No.: HY-146676

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UR-MB108

UR-MB108 is a selective ABCG2 inhibitor with an IC₅₀ value of 79 nM. UR-MB108 acts as a potent inhibitor of ABCG2 transport and ATPase activity. UR-MB108 can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2412461-98-2
Formula: C₄₀H₃₈N₆O₄
Molecular Weight:666.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

UR-MB108 Chemical Structure

CAS No.: 2412461-98-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC₅₀: 79 nM (ABCG2 (BCRP))^[1]

In Vitro

UR-MB108 potently inhibits ABCG2-mediated Hoechst 33342 efflux in MCF-7/Topo cells with an IC₅₀ of 79 nM and a maximal inhibitory effect of 91%, and shows no inhibitory activity against ABCB1 or ABCC1 transporters^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2412461-98-2
Molecular Weight 666.77
Formula C₄₀H₃₈N₆O₄
SMILES

CCC(C1=CC=C(C=C1NC(C2=NC3=C(C=C2)C=CC=C3)=O)C4=CN(N=N4)C5=CC=C(C=C5)CCN6CCC7=C(C6)C=C(C(OC)=C7)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Antoni F, et al. Water-soluble inhibitors of ABCG2 (BCRP) - A fragment-based and computational approach. Eur J Med Chem. 2021;210:112958. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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