UR-MB108
UR-MB108 is a selective ABCG2 inhibitor with an IC50 value of 79 nM. UR-MB108 acts as a potent inhibitor of ABCG2 transport and ATPase activity. UR-MB108 can be used in cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 2412461-98-2
- Formula: C40H38N6O4
- Molecular Weight:666.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 79 nM (ABCG2 (BCRP))[1]
UR-MB108 potently inhibits ABCG2-mediated Hoechst 33342 efflux in MCF-7/Topo cells with an IC50 of 79 nM and a maximal inhibitory effect of 91%, and shows no inhibitory activity against ABCB1 or ABCC1 transporters[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2412461-98-2
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Molecular Weight 666.77
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Formula C40H38N6O4
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SMILES
CCC(C1=CC=C(C=C1NC(C2=NC3=C(C=C2)C=CC=C3)=O)C4=CN(N=N4)C5=CC=C(C=C5)CCN6CCC7=C(C6)C=C(C(OC)=C7)OC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UR-MB108 Related Classifications
HY-146676 Related Classifications
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