Triclabendazole sulfoxide (Synonyms: TCBZ-SO)

Cat. No.: HY-136450: FAQs
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Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP.

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Triclabendazole sulfoxide Chemical Structure

CAS No. : 100648-13-3

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Description	Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole, and exhibits anti-parasite effects. Triclabendazole sulfoxide can inhibit membrane transporter ABCG2/BCRP^[1]^[2].
Molecular Weight	375.66
Formula	C₁₄H₉Cl₃N₂O₂S
CAS No.	100648-13-3
SMILES	O=S(C1=NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N1)C
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Barrera B, et, al. The anthelmintic triclabendazole and its metabolites inhibit the membrane transporter ABCG2/BCRP. Antimicrob Agents Chemother. 2012 Jul;56(7):3535-43. [Content Brief] [2]. Robinson MW, et, al. The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica. Parasitol Res. 2004 Feb;92(3):205-10. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Triclabendazole sulfoxide100648-13-3TCBZ-SOParasiteBCRPBreast cancer resistance proteinABCG2Inhibitorinhibitorinhibit

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Triclabendazole sulfoxide (Synonyms: TCBZ-SO)

View All Parasite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

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