1. Membrane Transporter/Ion Channel
  2. BCRP

KS176 

Cat. No.: HY-19753 Purity: 98.92%
Handling Instructions

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.

For research use only. We do not sell to patients.

KS176 Chemical Structure

KS176 Chemical Structure

CAS No. : 1253452-78-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1188 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay). Target: BCRP The more detailed information please refer to Compound 9 in the reference.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (86.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4667 mL 12.3335 mL 24.6670 mL
5 mM 0.4933 mL 2.4667 mL 4.9334 mL
10 mM 0.2467 mL 1.2333 mL 2.4667 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

405.4

Formula

C₂₂H₁₉N₃O₅

CAS No.

1253452-78-6

SMILES

O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)C=C2)=O)C=CC=C1)NC3=CC=C(CCO)C=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
KS176
Cat. No.:
HY-19753
Quantity:

KS176

Cat. No.: HY-19753