1. Membrane Transporter/Ion Channel
  2. BCRP
  3. KS176

KS176 

Cat. No.: HY-19753 Purity: 98.01%
COA Handling Instructions

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.

For research use only. We do not sell to patients.

KS176 Chemical Structure

KS176 Chemical Structure

CAS No. : 1253452-78-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 118 In-stock
Solution
10 mM * 1 mL in DMSO USD 118 In-stock
Solid
1 mg USD 51 In-stock
5 mg USD 108 In-stock
10 mg USD 180 In-stock
50 mg USD 720 In-stock
100 mg USD 1188 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE KS176

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1. IC50 value: 0.59( in Pheo A assay), 1.39 μM (in Hoechst 33342 assay). Target: BCRP The more detailed information please refer to Compound 9 in the reference.

Molecular Weight

405.40

Formula

C22H19N3O5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(NC(C2=CC=C([N+]([O-])=O)C=C2)=O)C=CC=C1)NC3=CC=C(CCO)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 35 mg/mL (86.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4667 mL 12.3335 mL 24.6670 mL
5 mM 0.4933 mL 2.4667 mL 4.9334 mL
10 mM 0.2467 mL 1.2333 mL 2.4667 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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KS176 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
KS176
Cat. No.:
HY-19753
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