2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis Antibiotic
  4. Danofloxacin

Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens.

For research use only. We do not sell to patients.

Danofloxacin

Danofloxacin Chemical Structure

CAS No. : 112398-08-0

Size Price Stock Quantity
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Danofloxacin:

Danofloxacin Related Antibodies

Top Publications Citing Use of Products

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

View All Antibiotic Isoform Specific Products:

View All Isoforms
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Danofloxacin is an orally active quinolone antibiotic. Danofloxacin targets bacterial DNA gyrase and inhibits bacterial DNA replication, transcription and growth. Danofloxacin can be used for various bacterial infections caused by Escherichia coli, Mycoplasma and other pathogens[1][2][3].

IC50 & Target

Quinolone

 

In Vitro

Danofloxacin (20 h) exhibits significant in vitro inhibitory activity against Escherichia coli isolates from Gushi chickens, with an MIC50 of 0.5 μg/mL; the MIC50 against the quality control strain E. coli ATCC 25922 is 0.125 μg/mL[1].
Danofloxacin (0.008-128 μg/mL; 20 h) exhibits certain inhibitory activity against swine-derived Escherichia coli isolates, with an MIC50 of 4 μg/mL and an MIC90 of 128 μg/mL. The epidemiological cut-off value covering the wild-type population is 8 μg/mL[3].
Danofloxacin (1/4 MIC-32× MIC; 0-24 h) exhibits concentration-dependent bactericidal activity against the Escherichia coli strain JLP95, with significant efficacy observed at concentrations of 4× MIC and above[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Danofloxacin Related Antibodies
In Vivo

Danofloxacin (5 mg/kg; p.o. via gavage; every 24 h; 3 consecutive days) with multiple oral administration to healthy Gushi chickens results in widespread tissue distribution, prolonged retention in skin + fat, liver, and lung, and requires a 6-day withdrawal period to meet regulatory residue limits[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

357.38

Formula

C19H20FN3O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4[C@](C5)([H])CN(C)[C@]5([H])C4)=C3)C1=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1 M NaOH : 100 mg/mL (279.81 mM; ultrasonic and warming and heat to 60°C)

H2O : 2 mg/mL (5.60 mM; ultrasonic and warming and adjust pH to 11 with 1 M NaOH and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7981 mL 13.9907 mL 27.9814 mL
5 mM 0.5596 mL 2.7981 mL 5.5963 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.56%

SDS (557 KB)

COA (250 KB) HNMR (294 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 1 M NaOH 1 mM 2.7981 mL 13.9907 mL 27.9814 mL 69.9535 mL
5 mM 0.5596 mL 2.7981 mL 5.5963 mL 13.9907 mL
1 M NaOH 10 mM 0.2798 mL 1.3991 mL 2.7981 mL 6.9954 mL
15 mM 0.1865 mL 0.9327 mL 1.8654 mL 4.6636 mL
20 mM 0.1399 mL 0.6995 mL 1.3991 mL 3.4977 mL
25 mM 0.1119 mL 0.5596 mL 1.1193 mL 2.7981 mL
30 mM 0.0933 mL 0.4664 mL 0.9327 mL 2.3318 mL
40 mM 0.0700 mL 0.3498 mL 0.6995 mL 1.7488 mL
50 mM 0.0560 mL 0.2798 mL 0.5596 mL 1.3991 mL
60 mM 0.0466 mL 0.2332 mL 0.4664 mL 1.1659 mL
80 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8744 mL
100 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6995 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Danofloxacin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danofloxacin112398-08-0BacterialDNA/RNA SynthesisAntibioticmycoplasma infectionsavian colibacillosisescherichia coli infectionsswine Escherichia colipneumoniaswine colibacillosisbacterial DNA gyraseavian pathogenic Escherichia coliGushi chickensbacterial DNA replicationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Danofloxacin
Cat. No.:
HY-W011117
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (557 KB) Français - FR (557 KB) Deutsch - DE (557 KB) Norwegian - NO (557 KB) Español - ES (557 KB) Swedish - SV (557 KB) Italian - IT (557 KB) Korean - KR (557 KB) Portuguese - PT (557 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.