1. Metabolic Enzyme/Protease Anti-infection
  2. Mitochondrial Metabolism Parasite
  3. Thiabendazole

Thiabendazole  (Synonyms: Tiabendazole; 2-(4-Thiazolyl)benzimidazole)

Cat. No.: HY-B0263 Purity: 99.65%
COA Handling Instructions

Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.

For research use only. We do not sell to patients.

Thiabendazole Chemical Structure

Thiabendazole Chemical Structure

CAS No. : 148-79-8

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 28 In-stock
10 mM * 1 mL in DMSO USD 28 In-stock
500 mg USD 25 In-stock
1 g USD 35 In-stock
5 g USD 50 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thiabendazole:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Thiabendazole

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property. Target: Fumarate Reductase Tiabendazole serves to block angiogenesis in both frog embryos and human cells. It has also been shown to serve as a vascular disrupting agent to reduce newly established blood vessels. Tiabendazole has been shown to effectively do this in certain cancer cells. Thiabendazole works by inhibition of the mitochondrial, helminth-specific enzyme, fumarate reductase, with possible interaction with endogenous quinone [1]. Thiabendazole inhibited B16F10 proliferation in vitro in a dose- and time-dependent manner with an IC50 of 532.4 +/- 32.6, 322.9 +/- 28.9, 238.5 +/- 19.8 microM at 24, 48, and 72 h, respectively. Moreover, thiabendazole inhibited the angiogenesis and the migration of B16F10 cells in vitro. Furthermore, thiabendazole restrained transcription and translation of the VEGF gene in B16F10 in vitro, and the apoptotic percentage of B16F10 cells was increased after exposure to thiabendazole [2].

Molecular Weight







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Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (248.45 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9689 mL 24.8447 mL 49.6894 mL
5 mM 0.9938 mL 4.9689 mL 9.9379 mL
10 mM 0.4969 mL 2.4845 mL 4.9689 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (12.42 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.72%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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