2. Anti-infection
  3. Bacterial Antibiotic
  4. Nitrofurantoin

Nitrofurantoin 

Cat. No.: HY-A0090 Purity: 99.42%
COA Handling Instructions

Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections.

For research use only. We do not sell to patients.

Nitrofurantoin Chemical Structure

Nitrofurantoin Chemical Structure

CAS No. : 67-20-9

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Nitrofurantoin:

Nitrofurantoin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections[1].

IC50 & Target

β-lactam

 

In Vitro

Nitrofurantoin (0-512 mg/L; 8 h) treatment inhibits the growth of E. coli isolates[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nitrofurantoin Related Antibodies

Cell Viability Assay[3]

Cell Line: E. coli isolates: DA10708, DA13815, DA13824, DA13957, DA13992, DA10626, DA10627
Concentration: 0, 32, 64, 128, 256, and 512 mg/L
Incubation Time: 8 hours
Result: Observed bactericidal effect at 32 mg/L For DA10708, DA13815 and DA13824.
Inhibited the growth of DA13957 and DA13992 completely at 128 mg/L, observed bactericidal effect at 256 mg/L.
Showed a moderate killing at >128 mg/L for DA10626 and DA10627.
In Vivo

1.19 Nitrofurantoin pharmacokinetic effects in SD Rats[4].

Parameters 10 mg/kg p.o. 2 mg/kg i.v.
AUC0-720 (μg/mL·min) 306
AUC0-120 (μg/mL·min) 90.3
AUC0-∞ (μg/mL·min) 344 91.5
Cmax (μg/mL) 1.01
CL/F or CL (ml/min/kg) 31.0 22.7
t1/2 (min) 166 23.6
Bioavailability (%) 60.1

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

238.16

Appearance

Solid

Formula

C8H6N4O5
CAS No.
SMILES

O=C1NC(CN1/N=C/C2=CC=C([N+]([O-])=O)O2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (419.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1989 mL 20.9943 mL 41.9886 mL
5 mM 0.8398 mL 4.1989 mL 8.3977 mL
10 mM 0.4199 mL 2.0994 mL 4.1989 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.42%

COA (248 KB) LCMS (111 KB)

Handling Instructions (2659 KB)
References
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Nitrofurantoin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Nitrofurantoin67-20-9BacterialAntibioticantimicrobialantibioticurinary tractinfectionUTIcystitiskidneyE. coliInhibitorinhibitorinhibit

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