2. Anti-infection
  3. Bacterial Antibiotic
  4. Nitrofurantoin

Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections.

For research use only. We do not sell to patients.

Nitrofurantoin Chemical Structure

Nitrofurantoin Chemical Structure

CAS No. : 67-20-9

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Based on 6 publication(s) in Google Scholar

Other Forms of Nitrofurantoin:

Nitrofurantoin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections[1].

IC50 & Target

β-lactam

 

In Vitro

Nitrofurantoin (0-512 mg/L; 8 h) treatment inhibits the growth of E. coli isolates[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nitrofurantoin Related Antibodies

Cell Viability Assay[3]

Cell Line: E. coli isolates: DA10708, DA13815, DA13824, DA13957, DA13992, DA10626, DA10627
Concentration: 0, 32, 64, 128, 256, and 512 mg/L
Incubation Time: 8 hours
Result: Observed bactericidal effect at 32 mg/L For DA10708, DA13815 and DA13824.
Inhibited the growth of DA13957 and DA13992 completely at 128 mg/L, observed bactericidal effect at 256 mg/L.
Showed a moderate killing at >128 mg/L for DA10626 and DA10627.
In Vivo

1.19 Nitrofurantoin pharmacokinetic effects in SD Rats[4].

Parameters 10 mg/kg p.o. 2 mg/kg i.v.
AUC0-720 (μg/mL·min) 306
AUC0-120 (μg/mL·min) 90.3
AUC0-∞ (μg/mL·min) 344 91.5
Cmax (μg/mL) 1.01
CL/F or CL (ml/min/kg) 31.0 22.7
t1/2 (min) 166 23.6
Bioavailability (%) 60.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

238.16

Formula

C8H6N4O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1NC(CN1/N=C/C2=CC=C([N+]([O-])=O)O2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (419.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1989 mL 20.9943 mL 41.9886 mL
5 mM 0.8398 mL 4.1989 mL 8.3977 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.42%

COA (248 KB) LCMS (111 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1989 mL 20.9943 mL 41.9886 mL 104.9714 mL
5 mM 0.8398 mL 4.1989 mL 8.3977 mL 20.9943 mL
10 mM 0.4199 mL 2.0994 mL 4.1989 mL 10.4971 mL
15 mM 0.2799 mL 1.3996 mL 2.7992 mL 6.9981 mL
20 mM 0.2099 mL 1.0497 mL 2.0994 mL 5.2486 mL
25 mM 0.1680 mL 0.8398 mL 1.6795 mL 4.1989 mL
30 mM 0.1400 mL 0.6998 mL 1.3996 mL 3.4990 mL
40 mM 0.1050 mL 0.5249 mL 1.0497 mL 2.6243 mL
50 mM 0.0840 mL 0.4199 mL 0.8398 mL 2.0994 mL
60 mM 0.0700 mL 0.3499 mL 0.6998 mL 1.7495 mL
80 mM 0.0525 mL 0.2624 mL 0.5249 mL 1.3121 mL
100 mM 0.0420 mL 0.2099 mL 0.4199 mL 1.0497 mL
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Nitrofurantoin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nitrofurantoin67-20-9BacterialAntibioticantimicrobialantibioticurinary tractinfectionUTIcystitiskidneyE. coliInhibitorinhibitorinhibit

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