2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. MC70

MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1.

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MC70 Chemical Structure

MC70 Chemical Structure

CAS No. : 1031367-64-2

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5 mg USD 85 In-stock
10 mg USD 135 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
100 mg USD 720 In-stock
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Based on 1 publication(s) in Google Scholar

MC70 Related Antibodies

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Description

MC70 is a potent and non-selective P-glycoprotein (P-gp) inhibitor with an EC50 of 0.69 µM. MC70 is an ABC transporters inhibitor and anticancer agent. MC70 interacts with ABCB1, ABCG2 and ABCC1[1][2].

IC50 & Target

EC50: 0.69 µM (P-glycoprotein)[1]
Molecular Weight

375.46

Formula

C24H25NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C2=CC=C(CN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (665.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6634 mL 13.3170 mL 26.6340 mL
5 mM 0.5327 mL 2.6634 mL 5.3268 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6634 mL 13.3170 mL 26.6340 mL 66.5850 mL
5 mM 0.5327 mL 2.6634 mL 5.3268 mL 13.3170 mL
10 mM 0.2663 mL 1.3317 mL 2.6634 mL 6.6585 mL
15 mM 0.1776 mL 0.8878 mL 1.7756 mL 4.4390 mL
20 mM 0.1332 mL 0.6658 mL 1.3317 mL 3.3292 mL
25 mM 0.1065 mL 0.5327 mL 1.0654 mL 2.6634 mL
30 mM 0.0888 mL 0.4439 mL 0.8878 mL 2.2195 mL
40 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6646 mL
50 mM 0.0533 mL 0.2663 mL 0.5327 mL 1.3317 mL
60 mM 0.0444 mL 0.2219 mL 0.4439 mL 1.1097 mL
80 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8323 mL
100 mM 0.0266 mL 0.1332 mL 0.2663 mL 0.6658 mL
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MC70 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MC701031367-64-2MC 70MC-70P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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