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Cat. No.: HY-156092

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Antitumor photosensitizer-4

Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells.

For research use only. We do not sell to patients.

Formula: C₆₅H₇₇ClN₁₂O₁₁S
Molecular Weight:1269.90

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Antitumor photosensitizer-4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
B16-F10	IC₅₀	0.48 μM Compound: 10b	Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay	[PMID: 37690263]
B16-F10	IC₅₀	38.34 μM Compound: 10b	Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under dark condition by CCK-8 assay Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under dark condition by CCK-8 assay	[PMID: 37690263]
HepG2	IC₅₀	0.44 μM Compound: 10b	Cytotoxicity against human HepG2 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay Cytotoxicity against human HepG2 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay	[PMID: 37690263]
HepG2	IC₅₀	56.17 μM Compound: 10b	Cytotoxicity against human HepG2 cells incubated for 48 hrs under dark condition by CCK-8 assay Cytotoxicity against human HepG2 cells incubated for 48 hrs under dark condition by CCK-8 assay	[PMID: 37690263]
HUVEC	IC₅₀	0.62 μM Compound: 10b	Cytotoxicity against human HUVEC cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay Cytotoxicity against human HUVEC cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay	[PMID: 37690263]
HUVEC	IC₅₀	39.61 μM Compound: 10b	Cytotoxicity against human HUVEC cells incubated for 48 hrs under dark condition by CCK-8 assay Cytotoxicity against human HUVEC cells incubated for 48 hrs under dark condition by CCK-8 assay	[PMID: 37690263]
L02	IC₅₀	0.54 μM Compound: 10b	Cytotoxicity against human L02 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay Cytotoxicity against human L02 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay	[PMID: 37690263]
L02	IC₅₀	26.34 μM Compound: 10b	Cytotoxicity against human L02 cells incubated for 48 hrs under dark condition by CCK-8 assay Cytotoxicity against human L02 cells incubated for 48 hrs under dark condition by CCK-8 assay	[PMID: 37690263]

In Vitro

Antitumor photosensitizer-4 arrests cell cycle at S phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antitumor photosensitizer-4 inhibits tumor growth and prolong survival time on BALB/c nude mice bearing HepG2 xenograft tumor^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1269.90
Formula C₆₅H₇₇ClN₁₂O₁₁S
SMILES

CC1=C(/C=C2[C@@H](C)[C@H](CCC(O)=O)C3=N/2)NC(/C=C4C(C)=C(CC)C(/C=C(N/5)/C(C)=C(C(O)=O)C5=C3/CC(NCCOCCOCCOCCC(OCCN6CCN(C7=CC(NC8=NC=C(C(NC9=C(C)C=CC=C9Cl)=O)S8)=NC(C)=N7)CC6)=O)=O)=N/4)=C1C=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang F, et al. Novel chlorin e6-based conjugates of tyrosine kinase inhibitors: Synthesis and photobiological evaluation as potent photosensitizers for photodynamic therapy. Eur J Med Chem. 2023 Sep 5;261:115787.. . [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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