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Art. -Nr.: HY-189709

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ABCG2-IN-6

ABCG2-IN-6 is a selective ABCG2 inhibitor that inhibits substrate efflux and stimulates ATPase activity. ABCG2-IN-6 can be used for breast cancer research.

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CAS. Nr.: 2378628-58-9
Formel: C₁₉H₁₉NO₃
Molecular Weight:309.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ABCG2-IN-6 Chemical Structure

CAS. Nr.: 2378628-58-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ABCG2-IN-6 is a selective ABCG2 inhibitor that inhibits substrate efflux and stimulates ATPase activity. ABCG2-IN-6 can be used for breast cancer research^[1].

IC₅₀ & Target

^[1]

ABCG2

In Vitro

Anti-cancerOthers

Anti-cancer

ABCG2-IN-6 (compound B5) (0.1-50 μM; 72 h) exhibits no cytotoxicity up to 5 μM and reverses ABCG2-mediated SN-38 (HY-13704)/Mitoxantrone (HY-13502) resistance in HEK293-ABCG2 and H460MX20 cells at 2.5 μM^[1].

Others

ABCG2-IN-6 (3-30 μM; 10-30 min) stimulates ABCG2-specific ATPase activity in A431-ABCG2 membrane preparations^[1].
ABCG2-IN-6 (0-30 μM; 30 min) inhibits ABCG2-mediated Hoechst 33342 efflux in HEK293-ABCG2 cells with an IC₅₀ of 2.70 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK293, HEK293-ABCG2, H460, H460MX20
Concentration:

0.1-50 μM (B5); 2.5 μM (B5 with SN-38 0.5 μM); 2.5 μM (B5 with Mitoxantrone 0.5 μM)
Incubation Time:

72 h
Result:

Cotreatment with B5 (2.5 μM) restored SN-38 sensitivity in HEK293-ABCG2 and H460MX20 cells to levels comparable to parental cells.
Chemosensitized H460MX20 cells to Mitoxantrone.

Related Protocols :

Breast Cancer Modeling

Chemical Information

CAS. Nr. 2378628-58-9
Molecular Weight 309.36
Formel C₁₉H₁₉NO₃
SMILES

CC(NC1=CC=C(C(/C=C/C2=CC=C(OCC)C=C2)=O)C=C1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Gomes de Oliveira AH, et al. Identification of the Acetamide-Chalcone Derivative That Selectively Inhibits ABCG2 Transport Activity. ACS omega. 2026 Sep 22;11(37):56373-56383.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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