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Cat. No.: HY-W843469

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1-Hydroxyacridin-9(10H)-one

1-Hydroxyacridin-9 (10H)-one (Compound 2a) is an Acridone (HY-W007771) derivative. 1-Hydroxyacridin-9 (10H)-one does not inhibit ABCG2-mediated efflux of Mitoxantrone (HY-13502), with an IC₅₀ > 20 μM.

For research use only. We do not sell to patients.

CAS No.: 65582-54-9
Formula: C₁₃H₉NO₂
Molecular Weight:211.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

1-Hydroxyacridin-9(10H)-one Chemical Structure

CAS No.: 65582-54-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HaCaT	IC₅₀	>50 μM Compound: 5	Antiproliferative activity against human HaCaT cells assessed as dispersed cells after 48 hrs by phase-contrast microscopic analysis Antiproliferative activity against human HaCaT cells assessed as dispersed cells after 48 hrs by phase-contrast microscopic analysis	[PMID: 20850910]
HaCaT	IC₅₀	>50 μM Compound: 5a	Antiproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopy Antiproliferative activity against human HaCaT cells after 48 hrs by phase contrast microscopy	[PMID: 20452101]
HEK293	IC₅₀	>20 μM Compound: 2a	Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry Inhibition of ABCG2 expressed in HEK293 cells assessed as mitoxantrone-mediated efflux by flow cytometry	[PMID: 17317193]

Chemical Information

CAS No. 65582-54-9
Molecular Weight 211.22
Formula C₁₃H₉NO₂
SMILES

O=C1C=2C=CC=CC2NC=3C=CC=C(O)C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Boumendjel A, et al. Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2. Bioorganic & medicinal chemistry. 2007 Apr 15;15(8):2892-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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