ASAP1 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 Gene

Homo sapiens

Also known as PAP; PAG2; AMAP1; DDEF1; ZG14P; CENTB4

Gene ID: 50807 | Gene type: protein coding

About ASAP1

Cytogenetic location: 8q24.21-q24.22 Genomic coordinates (GRCh38): 8:130,052,104-130,443,674 (from NCBI)

This gene has 16 transcripts (splice variants), 240 orthologues and 28 paralogues. Ubiquitous expression in bone marrow (RPKM 18.3), spleen (RPKM 15.5) and 24 other tissues.

Summary

This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and Cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

ASAP1 Products(5)

mRNA	Protein	Name
NM_001247996.2	NP_001234925.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
NM_001362924.1	NP_001349853.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3
NM_001362925.2	NP_001349854.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4
NM_001362926.2	NP_001349855.1	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5
NM_018482.4	NP_060952.2	arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1

ASAP1 Protein Structure

ArfGap

Ank_2

SH3_1

0
200
400
600
800
1000
1129 a.a.

Protein Preferred Names

Protein Names

arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein

Related Diseases

Diseases

Alias

Laryngeal Benign Neoplasm

Laryngeal Tumor	Larynx Neoplasm
Neoplasm Of Larynx	Laryngeal Cancer
Laryngeal Carcinoma	Cancer Of Larynx

Melanoma, Uveal

Uveal Melanoma	Choroidal Melanoma
Melanoma Of Uvea	Iris Melanoma
Malignant Melanoma Of Choroid	Malignant Melanoma Of Iris

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01055	ASAP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ASAP1	VGNC	VGNC:59952
Mus musculus	ASAP1	MGD	MGI:1342335
Rattus norvegicus	ASAP1	RGD	RGD:1307379
Macaca mulatta	ASAP1	VGNC	VGNC:69918
Canis familiaris	ASAP1	VGNC	VGNC:38153
Bos taurus	ASAP1	VGNC	VGNC:26184

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