1. Vitamin D Related/Nuclear Receptor Autophagy
  2. p62 Nuclear Hormone Receptor 4A/NR4A
  3. Triptohypol C

Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1.

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Triptohypol C Chemical Structure

Triptohypol C Chemical Structure

CAS No. : 193957-88-9

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Based on 1 publication(s) in Google Scholar

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Description

Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].

IC50 & Target

Nur77/NR4A1

 

In Vitro

Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Lysates from HepG2 cells (incubated with 20 ng/mL TNFα for 30 min)
Concentration: 2 μM
Incubation Time: 1 h
Result: Strongly antagonized the effect of TNFα on inducing IκBα degradation

Immunofluorescence[1]

Cell Line: HepG2 cells (transfected with Myc-Nur77 and Flag-TRAF2 or Flag-p62)
Concentration: 2 μM
Incubation Time: 1 h
Result: Promoted the interactions between Nur77 and TRAF2 and p62/SQSTM1.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 10 h
Result: Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).
In Vivo

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish[1]
Dosage: 0.5 μM, 1 μM and 1.25 μM
Administration: 72 h
Result: Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25 μM for 24 h or at a concentration of 0.5 μM for 72 h.
Molecular Weight

452.63

Formula

C29H40O4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=C(O)C(O)=CC2=C1CC=C3[C@@]2(C)CC[C@]4(C)[C@]3(C)CC[C@]5(C)[C@@]4([H])C[C@](C)(C(O)=O)CC5

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: 95.44%

References
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Triptohypol C
Cat. No.:
HY-117469
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