MAP2K5 - mitogen-activated protein kinase kinase 5 Gene

Also Known as MEK5; MAPKK5; PRKMK5; HsT17454

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5607

About MAP2K5

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:67,542,703-67,807,114 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 8 paralogues. Ubiquitous expression in ovary (RPKM 2.0), testis (RPKM 1.9) and 25 other tissues.

Summary

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

MAP2K5 Products (10)

mRNA	Protein	Name
XM_011521788.4	XP_011520090.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X2
XM_017022414.3	XP_016877903.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X3
NM_002757.4	NP_002748.1	dual specificity mitogen-activated protein kinase kinase 5 isoform B
XM_011521787.4	XP_011520089.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X1
XM_047432856.1	XP_047288812.1	dual specificity mitogen-activated protein kinase kinase 5 isoform X4
NM_145162.1
NM_145160.3	NP_660143.1	dual specificity mitogen-activated protein kinase kinase 5 isoform A
NM_001206804.2	NP_001193733.1	dual specificity mitogen-activated protein kinase kinase 5 isoform C
NM_145161.1
XR_007064474.1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7759517	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP2K5 Protein Structure

PB1

Pkinase

0
100
200
300
400
448 a.a.

Protein Preferred Names	Protein Names
dual specificity mitogen-activated protein kinase kinase 5	MAP kinase kinase 5 MAP kinase kinase MEK5b MAPK/ERK kinase 5 MAPKK 5 MEK 5

MAP2K5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAP2K5	Q13163	GUCD1	Homo sapiens	Q96NT3-2	Validated Y2H	32296183
Intra	MAP2K5	Q13163	GUCD1	Homo sapiens	Q96NT3-2	Y2H Array	32296183
Intra	MAP2K5	Q13163	GUCD1	Homo sapiens	Q96NT3-2	Y2H Prey Pooling	32296183
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Y2H Prey Pooling	32296183
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Pull Down	32707033
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Anti Tag CoIP	28514442
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Y2H	7759517
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Validated Y2H	32296183
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Anti Tag CoIP	33961781
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Pull Down	7759517
Intra	MAP2K5	Q13163	MAPK7	Homo sapiens	Q13164	Y2H Array	32296183
Intra	MAP2K5	Q13163	C3orf36	Homo sapiens	Q3SXR2	Y2H Array	32296183
Intra	MAP2K5	Q13163	C3orf36	Homo sapiens	Q3SXR2	Y2H Prey Pooling	32296183
Intra	MAP2K5	Q13163	C3orf36	Homo sapiens	Q3SXR2	Validated Y2H	32296183
Intra	MAP2K5	Q13163	LNX2	Homo sapiens	Q8N448	Y2H Array	29892012
Intra	MAP2K5	Q13163	LNX2	Homo sapiens	Q8N448	Y2H	21516116
Intra	MAP2K5	Q13163	LNX2	Homo sapiens	Q8N448	Y2H Array	31515488
Intra	MAP2K5	Q13163	SQSTM1	Homo sapiens	Q13501	Anti Tag CoIP	31980649
Intra	MAP2K5	Q13163	SQSTM1	Homo sapiens	Q13501	Validated Y2H	32296183
Intra	MAP2K5	Q13163	SQSTM1	Homo sapiens	Q13501	Y2H Array	32296183
Intra	MAP2K5	Q13163	MAP3K3	Homo sapiens	Q99759	Pull Down	32707033
Intra	MAP2K5	Q13163	MAP3K3	Homo sapiens	Q99759	Anti Tag CoIP	33961781
Intra	MAP2K5	Q13163	MAP3K3	Homo sapiens	Q99759	TAP	14743216
Intra	MAP2K5	Q13163	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	MAP2K5	Q13163	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	MAP2K5	Q13163	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	MAP2K5	Q13163	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	MAP2K5	Q13163	PFDN5	Homo sapiens	Q99471	Y2H Array	32296183
Intra	MAP2K5	Q13163	MAP3K2	Homo sapiens	Q9Y2U5	Pull Down	32707033
Intra	MAP2K5	Q13163	MAP3K2	Homo sapiens	Q9Y2U5	Anti Tag CoIP	31980649
Intra	MAP2K5	Q13163	MAP3K2	Homo sapiens	Q9Y2U5	Anti Tag CoIP	33961781
Intra	MAP2K5	Q13163	MAP3K2	Homo sapiens	Q9Y2U5	Anti Tag CoIP	28514442
Intra	MAP2K5	Q13163	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Intra	MAP2K5	Q13163	ZNF620	Homo sapiens	Q6ZNG0	Y2H Prey Pooling	32296183
Intra	MAP2K5	Q13163	ZNF620	Homo sapiens	Q6ZNG0	Validated Y2H	32296183
Intra	MAP2K5	Q13163	ZNF620	Homo sapiens	Q6ZNG0	Y2H Array	32296183
Intra	MAP2K5	Q13163	DUSP21	Homo sapiens	Q9H596	Validated Y2H	32296183
Intra	MAP2K5	Q13163	DUSP21	Homo sapiens	Q9H596	Y2H Array	32296183
Intra	MAP2K5	Q13163	DUSP21	Homo sapiens	Q9H596	Y2H Prey Pooling	32296183
Intra	MAP2K5	Q13163	ZNF426	Homo sapiens	Q9BUY5	Y2H Prey Pooling	32296183
Intra	MAP2K5	Q13163	ZNF426	Homo sapiens	Q9BUY5	Y2H Array	32296183
Intra	MAP2K5	Q13163	ZNF426	Homo sapiens	Q9BUY5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MAP2K5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83395	MEK5 Antibody (YA3140)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A	/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAP2K5	RGD	RGD:61890
Mus musculus	MAP2K5	MGD	MGI:1346345
Felis catus	MAP2K5	VGNC	VGNC:104488
Canis familiaris	MAP2K5	VGNC	VGNC:42963
Macaca mulatta	MAP2K5	VGNC	VGNC:81455
Bos taurus	MAP2K5	VGNC	VGNC:31186
Others	MAP2K5	NCBI