MAP3K2 - mitogen-activated protein kinase kinase kinase 2 Gene

Also Known as MEKK2; MEKK2B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10746

About MAP3K2

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,298,668-127,388,465 (from NCBI)

This gene has 3 transcripts (splice variants), 217 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 11.2), thyroid (RPKM 10.3) and 25 other tissues.

Summary

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates Other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]

MAP3K2 Products (3)

mRNA Protein Name
NM_001371910.2 NP_001358839.1 mitogen-activated protein kinase kinase kinase 2
NM_001371911.1 NP_001358840.1 mitogen-activated protein kinase kinase kinase 2
NM_006609.5 NP_006600.3 mitogen-activated protein kinase kinase kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15778465 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
15001576 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
17906693 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19593445 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
14515274 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP3K2 Protein Structure

PB1

PB1: PB1 domain (44 - 120)

Pkinase

Pkinase: Protein kinase domain (356 - 615)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase 2

  • MAP/ERK kinase kinase 2

MAP3K2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP3K2 Q9Y2U5 MAP2K5 Homo sapiens Q13163
Y2H Array
21988832
Intra
MAP3K2 Q9Y2U5 MAP2K5 Homo sapiens Q13163
Pull Down
32707033
Intra
MAP3K2 Q9Y2U5 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
MAP3K2 Q9Y2U5 YWHAE Homo sapiens P62258
Anti Tag CoIP
26496610
Intra
MAP3K2 Q9Y2U5 YWHAE Homo sapiens P62258
Pull Down
32707033
Intra
MAP3K2 Q9Y2U5 STUB1 Homo sapiens Q9UNE7
Anti Tag CoIP
20588253
Intra
MAP3K2 Q9Y2U5 STUB1 Homo sapiens Q9UNE7
Anti Bait CoIP
20588253
Intra
MAP3K2 Q9Y2U5 SFN Homo sapiens P31947
TAP
15778465
Intra
MAP3K2 Q9Y2U5 SFN Homo sapiens P31947
Anti Tag CoIP
26496610
Cross: Cross-species interaction Intra: Intraspecies interaction

MAP3K2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83470 MEKK2 Antibody (YA3215) WB, ICC/IF, IP Human, Mouse, Rat
HY-P83470A MEKK2 Antibody (YA3215)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat
HY-P85273 MEKK2 Antibody (YA4965) IHC-P, IHC-F, ICC/IF, IF-Tissue, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112080A (R)-BAY-6035 Inhibitor / Unkown
HY-RS08054 MAP3K2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21882 Map3k2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28399 Map3k2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MAP3K2 VGNC VGNC:42972
Macaca mulatta MAP3K2 VGNC VGNC:81461
Mus musculus MAP3K2 MGD MGI:1346873
Rattus norvegicus MAP3K2 RGD RGD:620967
Felis catus MAP3K2 VGNC VGNC:80275
Bos taurus MAP3K2 VGNC VGNC:31195
Others MAP3K2 NCBI