MAPK7 - mitogen-activated protein kinase 7 Gene

Also Known as BMK1; ERK4; ERK5; PRKM7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5598

About MAPK7

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,377,750-19,383,544 (from NCBI)

This gene has 18 transcripts (splice variants), 193 orthologues and 19 paralogues. Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MAPK7 Products (15)

mRNA	Protein	Name
XM_006721558.4	XP_006721621.1	mitogen-activated protein kinase 7 isoform X1
XM_047436401.1	XP_047292357.1	mitogen-activated protein kinase 7 isoform X1
NM_002749.4	NP_002740.2	mitogen-activated protein kinase 7 isoform 1
NM_139034.3	NP_620603.2	mitogen-activated protein kinase 7 isoform 1
XM_047436406.1	XP_047292362.1	mitogen-activated protein kinase 7 isoform X2
XM_047436405.1	XP_047292361.1	mitogen-activated protein kinase 7 isoform X2
XM_006721559.4	XP_006721622.1	mitogen-activated protein kinase 7 isoform X1
XM_047436407.1	XP_047292363.1	mitogen-activated protein kinase 7 isoform X3
XM_047436404.1	XP_047292360.1	mitogen-activated protein kinase 7 isoform X2
NM_139032.3	NP_620601.1	mitogen-activated protein kinase 7 isoform 2
XM_047436402.1	XP_047292358.1	mitogen-activated protein kinase 7 isoform X1
XM_011523957.4	XP_011522259.1	mitogen-activated protein kinase 7 isoform X4
XM_006721557.4	XP_006721620.1	mitogen-activated protein kinase 7 isoform X1
XM_047436403.1	XP_047292359.1	mitogen-activated protein kinase 7 isoform X1
NM_139033.3	NP_620602.2	mitogen-activated protein kinase 7 isoform 1

MAPK7 Protein Structure

Pkinase

0
200
400
600
816 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 7	BMK-1 BMK1 kinase ERK-5 MAP kinase 7 MAPK 7 big MAP kinase 1 extracellular-signal-regulated kinase 5

MAPK7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAPK7	Q13164	UBE2C	Homo sapiens	Q5TZN3	Y2H Prey Pooling	25416956
Intra	MAPK7	Q13164	UBE2C	Homo sapiens	Q5TZN3	Validated Y2H	25416956
Intra	MAPK7	Q13164	CCDC6	Homo sapiens	Q16204	Validated Y2H	32296183
Intra	MAPK7	Q13164	PML	Homo sapiens	P29590	Anti Bait CoIP	20832753
Intra	MAPK7	Q13164	PML	Homo sapiens	P29590	IF	20832753
Intra	MAPK7	Q13164	BAG2	Homo sapiens	O95816	Anti Tag CoIP	31980649

Cross: Cross-species interaction Intra: Intraspecies interaction

MAPK7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80122	ERK5 Antibody (YA451)	WB, ICC/IF, IP, FC	Human, Mouse
HY-P84530	ERK5 Antibody (YA4227)	IHC-P, ELISA	Human
HY-P84530A	ERK5 Antibody (YA4227)(PBS only)	IHC-P, ELISA	Human
HY-P85724	ERK5 Antibody (YA5416)	IHC-P, WB	Human, Mouse, Rat
HY-P86354	ERK5 Antibody (YA6046)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Multiple Endocrine Neoplasia, Type Iia	Multiple Endocrine Neoplasia Type 2a Sipple Syndrome Multiple Endocrine Neoplasia Type 2 MEN2A Men2 Ptc Syndrome Multiple Endocrine Neoplasia, Type 2 Multiple Endocrine Neoplasia Iia Men 2a Multiple Endocrine Neoplasia, Type 2a Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Ii Men2 Syndrome Men-2a Syndrome Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma Multiple Neoplasia 2a Multiple Neoplasia Type 2
Scoliosis
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Purulent Acute Otitis Media	Acute Suppurative Otitis Media Acute Or Subacute Suppurative Otitis Media Acute Or Subacute Purulent Otitis Media
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Scoliosis, Isolated 1	Adolescent Idiopathic Scoliosis Scoliosis, Isolated, Susceptibility To, 1 Ais IS1 Adolescent Isolated Scoliosis Scoliosis, Idiopathic 1 Late Onset Idiopathic Scoliosis Idiopathic Adolescent Scoliosis Scoliosis, Idiopathic, Susceptibility To, Type 1
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Neuropathy, Hereditary Sensory And Autonomic, Type Iia	Hereditary Sensory And Autonomic Neuropathy Type 2 Hsan2 HSAN2A Morvan Disease Hereditary Sensory And Autonomic Neuropathy Type Ii Neurogenic Acroosteolysis Hsan Iia Hsn2a Hsn Iia Neuropathy, Progressive Sensory, Of Children Neuropathy, Congenital Sensory Neuropathy, Hereditary Sensory And Autonomic, Type Ii Hereditary Sensory And Autonomic Neuropathy Type 2a Hereditary Sensory And Autonomic Neuropathy Type Iia Hsanii Congenital Sensory Neuropathy Hsan Type Ii Morvan Syndrome Neuropathy, Hereditary Sensory And Autonomic, Type 2a Neuropathy, Hereditary Sensory, Type Iia Acroosteolysis, Neurogenic Acroosteolysis, Giaccai Type Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive Hereditary Sensory Autonomic Neuropathy Type 2 Giaccai Type Acroosteolysis Hereditary Sensory Neuropathy Type 2 Hereditary Sensory Radicular Neuropathy, Recessive Form Hsan2b Hsan2c Hsan2d Hsn Type Ii Autosomal Recessive Sensory Radicular Neuropathy Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome Morvan Fibrillary Chorea Neuropathy, Hereditary Sensory And Autonomic, 2a Acroosteolysis Giaccai Type Hereditary Sensory Neuropathy Type Iia Hereditary Sensory Radicular Neuropathy Autosomal Recessive Progressive Sensory Neuropathy Of Children Neuropathy Congenital Sensory Charcot-Marie-Tooth Disease Neuropathy, Sensory And Autonomic, Hereditary, Type Iia Morvan'S Disease Hereditary Sensory Autonomic Neuropathy, Type 2 Hereditary Motor And Sensory-Neuropathy Type Ii Sensory Neuropathy, Hereditary Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-149412	MHJ-627	Inhibitor	/	Unkown
HY-RS08118	MAPK7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08119	Mapk7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08120	MAPK7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAPK7	VGNC	VGNC:68171
Bos taurus	MAPK7	VGNC	VGNC:31222
Mus musculus	MAPK7	MGD	MGI:1346347
Rattus norvegicus	MAPK7	RGD	RGD:621505
Canis familiaris	MAPK7	VGNC	VGNC:43000
Macaca mulatta	MAPK7	VGNC	VGNC:74648
Others	MAPK7	NCBI