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  2. MAPK7 - mitogen-activated protein kinase 7 Gene

MAPK7 - mitogen-activated protein kinase 7 Gene

Homo sapiens

Also known as BMK1; ERK4; ERK5; PRKM7

Gene ID: 5598 | Gene type: protein coding

About MAPK7

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,377,750-19,383,544 (from NCBI)

This gene has 18 transcripts (splice variants), 193 orthologues and 19 paralogues. Ubiquitous expression in testis (RPKM 7.6), ovary (RPKM 7.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

MAPK7 Products(15)

mRNA Protein Name
XM_006721558.4 XP_006721621.1 mitogen-activated protein kinase 7 isoform X1
XM_047436401.1 XP_047292357.1 mitogen-activated protein kinase 7 isoform X1
NM_002749.4 NP_002740.2 mitogen-activated protein kinase 7 isoform 1
NM_139034.3 NP_620603.2 mitogen-activated protein kinase 7 isoform 1
XM_047436406.1 XP_047292362.1 mitogen-activated protein kinase 7 isoform X2
XM_047436405.1 XP_047292361.1 mitogen-activated protein kinase 7 isoform X2
XM_006721559.4 XP_006721622.1 mitogen-activated protein kinase 7 isoform X1
XM_047436407.1 XP_047292363.1 mitogen-activated protein kinase 7 isoform X3
XM_047436404.1 XP_047292360.1 mitogen-activated protein kinase 7 isoform X2
NM_139032.3 NP_620601.1 mitogen-activated protein kinase 7 isoform 2
XM_047436402.1 XP_047292358.1 mitogen-activated protein kinase 7 isoform X1
XM_011523957.4 XP_011522259.1 mitogen-activated protein kinase 7 isoform X4
XM_006721557.4 XP_006721620.1 mitogen-activated protein kinase 7 isoform X1
XM_047436403.1 XP_047292359.1 mitogen-activated protein kinase 7 isoform X1
NM_139033.3 NP_620602.2 mitogen-activated protein kinase 7 isoform 1

MAPK7 Protein Structure

Pkinase

Pkinase: Protein kinase domain (55 - 347)

  • 0
  • 200
  • 400
  • 600
  • 816 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 7

BMK-1

BMK1 kinase

ERK-5

MAP kinase 7

MAPK 7

big MAP kinase 1

extracellular-signal-regulated kinase 5

Related Diseases

Diseases Alias
Multiple Endocrine Neoplasia, Type Iia

Multiple Endocrine Neoplasia Type 2a

Sipple Syndrome

Multiple Endocrine Neoplasia Type 2

MEN2A

Men2

Ptc Syndrome

Multiple Endocrine Neoplasia, Type 2

Multiple Endocrine Neoplasia Iia

Men 2a

Multiple Endocrine Neoplasia, Type 2a

Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma

Multiple Endocrine Neoplasia Ii

Men2 Syndrome

Men-2a Syndrome

Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma

Multiple Neoplasia 2a

Multiple Neoplasia Type 2

Scoliosis
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Purulent Acute Otitis Media

Acute Suppurative Otitis Media

Acute Or Subacute Suppurative Otitis Media

Acute Or Subacute Purulent Otitis Media

Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome

Scoliosis, Isolated 1

Adolescent Idiopathic Scoliosis

Scoliosis, Isolated, Susceptibility To, 1

Ais

IS1

Adolescent Isolated Scoliosis

Scoliosis, Idiopathic 1

Late Onset Idiopathic Scoliosis

Idiopathic Adolescent Scoliosis

Scoliosis, Idiopathic, Susceptibility To, Type 1

Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p

Neuropathy, Hereditary Sensory And Autonomic, Type Iia

Hereditary Sensory And Autonomic Neuropathy Type 2

Hsan2

HSAN2A

Morvan Disease

Hereditary Sensory And Autonomic Neuropathy Type Ii

Neurogenic Acroosteolysis

Hsan Iia

Hsn2a

Hsn Iia

Neuropathy, Progressive Sensory, Of Children

Neuropathy, Congenital Sensory

Neuropathy, Hereditary Sensory And Autonomic, Type Ii

Hereditary Sensory And Autonomic Neuropathy Type 2a

Hereditary Sensory And Autonomic Neuropathy Type Iia

Hsanii

Congenital Sensory Neuropathy

Hsan Type Ii

Morvan Syndrome

Neuropathy, Hereditary Sensory And Autonomic, Type 2a

Neuropathy, Hereditary Sensory, Type Iia

Acroosteolysis, Neurogenic

Acroosteolysis, Giaccai Type

Neuropathy, Hereditary Sensory Radicular, Autosomal Recessive

Hereditary Sensory Autonomic Neuropathy Type 2

Giaccai Type Acroosteolysis

Hereditary Sensory Neuropathy Type 2

Hereditary Sensory Radicular Neuropathy, Recessive Form

Hsan2b

Hsan2c

Hsan2d

Hsn Type Ii

Autosomal Recessive Sensory Radicular Neuropathy

Limbic Encephalitis-Neuromyotonia-Hyperhidrosis-Polyneuropathy Syndrome

Morvan Fibrillary Chorea

Neuropathy, Hereditary Sensory And Autonomic, 2a

Acroosteolysis Giaccai Type

Hereditary Sensory Neuropathy Type Iia

Hereditary Sensory Radicular Neuropathy Autosomal Recessive

Progressive Sensory Neuropathy Of Children

Neuropathy Congenital Sensory

Charcot-Marie-Tooth Disease

Neuropathy, Sensory And Autonomic, Hereditary, Type Iia

Morvan'S Disease

Hereditary Sensory Autonomic Neuropathy, Type 2

Hereditary Motor And Sensory-Neuropathy Type Ii

Sensory Neuropathy, Hereditary

Neuropathy, Hereditary Sensory And Autonomic, Type Iib

Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus MAPK7 VGNC VGNC:68171
Bos taurus MAPK7 VGNC VGNC:31222
Mus musculus MAPK7 MGD MGI:1346347
Rattus norvegicus MAPK7 RGD RGD:621505
Canis familiaris MAPK7 VGNC VGNC:43000
Macaca mulatta MAPK7 VGNC VGNC:74648