hHR23A Antibody (YA2591)
(Synonyms: RAD23A; UV excision repair protein RAD23 homolog A; HR23A; hHR23A)hHR23A Antibody (YA2591) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hHR23A.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
hHR23A Antibody (YA2591) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to hHR23A.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 40 kDa
Entrez Gene: 5886 Human ; 19358 Mouse ; 361381 Rat
SwissProt: P54725 Human ; P54726 Mouse ;
OMIM: 600061 Human
A synthesized peptide derived from human RAD23A aa205-250/363.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
hHR23A is a Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC; (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
P54725 has 3 isomers: P54725-1: 39609 Da (predicted); P54725-2: 33433 Da (predicted); P54725-3: 39538 Da (predicted).
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Subunit
Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3 (PubMed:30455355). Interacts with UBQLN2
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SwissProt ID
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Synonyms
RAD23A; UV excision repair protein RAD23 homolog A; HR23A; hHR23A
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Research Field
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Documentation
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