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STIP1 - stress induced phosphoprotein 1 Gene

Also Known as HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10963

About STIP1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,185,272-64,204,543 (from NCBI)

This gene has 12 transcripts (splice variants), 210 orthologues and 18 paralogues. Ubiquitous expression in testis (RPKM 66.9), adrenal (RPKM 34.3) and 25 other tissues.

Summary

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

STIP1 Products (3)

mRNA	Protein	Name
NM_001282652.2	NP_001269581.1	stress-induced-phosphoprotein 1 isoform a
NM_001282653.2	NP_001269582.1	stress-induced-phosphoprotein 1 isoform c
NM_006819.3	NP_006810.1	stress-induced-phosphoprotein 1 isoform b

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	29127155	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20029029	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of protein folding chaperone complex	IDA IDA: Inferred from direct assay	29127155	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STIP1 Protein Structure

TPR_11

TPR_1

TPR_11

TPR_1

TPR_11

TPR_1

0
100
200
300
400
500
543 a.a.

Protein Preferred Names	Protein Names
stress-induced-phosphoprotein 1	Hsp70/Hsp90-organizing protein

STIP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STIP1	P31948	C3orf36	Homo sapiens	Q3SXR2	Y2H Array	32814053
Intra	STIP1	P31948	C3orf36	Homo sapiens	Q3SXR2	Validated Y2H	32814053
Intra	STIP1	P31948	C3orf36	Homo sapiens	Q3SXR2	Y2H Pooling	32814053
Intra	STIP1	P31948	CDC37L1	Homo sapiens	Q7L3B6	Lumier	25036637
Intra	STIP1	P31948	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	STIP1	P31948	CCDC117	Homo sapiens	Q8IWD4	Anti Tag CoIP	33961781
Intra	STIP1	P31948	CCDC117	Homo sapiens	Q8IWD4	Anti Tag CoIP	35271311
Intra	STIP1	P31948	CCDC117	Homo sapiens	Q8IWD4	Anti Tag CoIP	25036637
Intra	STIP1	P31948	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	28514442
Intra	STIP1	P31948	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	35271311
Intra	STIP1	P31948	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	STIP1	P31948	SPRY4	Homo sapiens	Q9C004	Validated Y2H	32814053
Intra	STIP1	P31948	SPRY4	Homo sapiens	Q9C004	Y2H Array	32814053
Intra	STIP1	P31948	SPRY4	Homo sapiens	Q9C004	Y2H Pooling	32814053
Intra	STIP1	P31948	CDS2	Homo sapiens	O95674	Validated Y2H	32814053
Intra	STIP1	P31948	CDS2	Homo sapiens	O95674	Y2H Pooling	32814053
Intra	STIP1	P31948	CDS2	Homo sapiens	O95674	Y2H Array	32814053
Intra	STIP1	P31948	MYC	Homo sapiens	P01106	Y2H Pooling	32814053
Intra	STIP1	P31948	MYC	Homo sapiens	P01106	Validated Y2H	32814053
Intra	STIP1	P31948	MYC	Homo sapiens	P01106	Y2H Array	32814053
Intra	STIP1	P31948	FOXD4L6	Homo sapiens	Q3SYB3	Y2H Array	32814053
Intra	STIP1	P31948	FOXD4L6	Homo sapiens	Q3SYB3	Validated Y2H	32814053
Intra	STIP1	P31948	FOXD4L6	Homo sapiens	Q3SYB3	Y2H Pooling	32814053
Intra	STIP1	P31948	POLA2	Homo sapiens	Q14181	Validated Y2H	32814053
Intra	STIP1	P31948	POLA2	Homo sapiens	Q14181	Y2H Array	32814053
Intra	STIP1	P31948	POLA2	Homo sapiens	Q14181	Y2H Pooling	32814053
Intra	STIP1	P31948	ACD	Homo sapiens	Q96AP0	Pull Down	21044950
Intra	STIP1	P31948	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32814053
Intra	STIP1	P31948	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32814053
Intra	STIP1	P31948	FAM9A	Homo sapiens	Q8IZU1	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

STIP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82335	STIP1 Antibody (YA2080)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P82335A	STIP1 Antibody (YA2080)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Microcephaly 7, Primary, Autosomal Recessive	MCPH7 Primary Autosomal Recessive Microcephaly 7 Microcephaly, Primary Autosomal Recessive, 7
Retinitis Pigmentosa 61	RP61 Retinitis Pigmentosa, Type 61
Chronic Wasting Disease	Wasting Disease, Chronic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09170	NECAB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13919	STIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14426	TFIP11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18548	Stip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25030	Stip1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STIP1	MGD	MGI:109130
Macaca mulatta	STIP1	VGNC	VGNC:101405
Felis catus	STIP1	VGNC	VGNC:81931
Rattus norvegicus	STIP1	RGD	RGD:621599
Canis familiaris	STIP1	VGNC	VGNC:46903
Others	STIP1	NCBI