SIKE1 - suppressor of IKBKE 1 Gene

Also Known as SIKE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80143

About SIKE1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,769,479-114,780,685 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.5), lymph node (RPKM 7.0) and 25 other tissues.

Summary

SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

SIKE1 Products (2)

mRNA Protein Name
NM_001102396.2 NP_001095866.1 suppressor of IKBKE 1 isoform 1
NM_025073.3 NP_079349.2 suppressor of IKBKE 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18782753 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
25743393 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
30622739 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
25743393 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of hippo signaling IDA
IDA: Inferred from direct assay
30622739 GOA
Cellular Component GO Annotation Evidence References Source
part of FAR/SIN/STRIPAK complex IDA
IDA: Inferred from direct assay
30622739 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIKE1 Protein Structure

SIKE

SIKE: SIKE family (1 - 188)

  • 0
  • 100
  • 207 a.a.
Protein Preferred Names Protein Names

suppressor of IKBKE 1

  • suppressor of IKK epsilon

SIKE1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SIKE1 Q9BRV8 STRN3 Homo sapiens Q13033-2
Anti Tag CoIP
26496610
Intra
SIKE1 Q9BRV8 STRN3 Homo sapiens Q13033-2
Y2H Prey Pooling
32296183
Intra
SIKE1 Q9BRV8 STRN3 Homo sapiens Q13033-2
Y2H Array
32296183
Intra
SIKE1 Q9BRV8 SCOC Homo sapiens Q9UIL1-3
Validated Y2H
32296183
Intra
SIKE1 Q9BRV8 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
SIKE1 Q9BRV8 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
SIKE1 Q9BRV8 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
Intra
SIKE1 Q9BRV8 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
Intra
SIKE1 Q9BRV8 CENPQ Homo sapiens Q7L2Z9
Y2H Prey Pooling
32296183
Intra
SIKE1 Q9BRV8 CENPQ Homo sapiens Q7L2Z9
Y2H Array
32296183
Intra
SIKE1 Q9BRV8 TRAF3IP3 Homo sapiens Q9Y228
Anti Tag CoIP
18782753
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Cavernous Malformations 3

  • Cerebral Cavernous Malformation 3

  • CCM3

  • Cerebral Cavernous Malformations-3

  • Cavernous Angiomatous Malformations

  • Cavernous Hemangioma Of The Brain

  • Cerebral Capillary Malformations

  • Cerebral Cavernoma

  • Familial Cavernous Angioma

  • Cerebral Cavernous Malformations, Type 3
Cerebral Cavernous Malformations

  • Cerebral Cavernous Malformation

  • Cavernous Malformations Of Cns And Retina

  • Cerebral Cavernous Malformation 1

  • Cavernous Angiomatous Malformations

  • Cerebral Capillary Malformations

  • CCM

  • Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

  • Familial Cavernous Angioma

  • Cavernous Angioma

  • Familial Cerebral Cavernous Malformation

  • Cerebral Cavernous Malformations 1

  • Cavernous Angioma, Familial

  • Cam

  • Cerebral Cavernous Malformations-1

  • Cavernoma

  • Central Nervous System Cavernous Hemangioma

  • Cerebral Cavernous Hemangioma

  • Familial Cavernous Hemangioma

  • Familial Cavernous Malformation

  • Familial Cerebral Cavernous Angioma

  • Intracerebral Cavernous Hemangioma

  • CCM1

  • Cavernous Hemangioma Of The Brain

  • Cerebral Cavernoma

  • Cerebral Cavernous Malformations, Type 1

  • Hemangioma, Cavernous, Central Nervous System

  • Hemangioma, Cavernous

  • Angioma, Cavernous
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12920 SIKE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SIKE1 VGNC VGNC:46172
Mus musculus SIKE1 MGD MGI:1913891
Macaca mulatta SIKE1 VGNC VGNC:77314
Bos taurus SIKE1 VGNC VGNC:34621
Rattus norvegicus SIKE1 RGD RGD:1311316
Felis catus SIKE1 VGNC VGNC:65145
Others SIKE1 NCBI