2. Protein Tyrosine Kinase/RTK
  3. RET
  4. RET-IN-23

RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity.

For research use only. We do not sell to patients.

RET-IN-23 Chemical Structure

RET-IN-23 Chemical Structure

CAS No. : 2479961-46-9

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RET-IN-23 Related Antibodies

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Description

RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity[1].

IC50 & Target

IC50: 1.32 nM (RET-WT); 2.50 nM (RET-CCDC6); 6.54 nM (RET-V804L); 1.03 nM (RET-V804M); 1.47 nM (RET-M918T)[1].
In Vivo

RET-IN-23 (5 mg/kg; p.o.) shows anti-tumor activity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c-nu mouse (TT cell subcutaneous xenograft tumor)[1]
Dosage: 5 mg/kg
Administration: P.o.
Result: Showed anti-tumor activity with T/C of 17.44%, TGI of 88.82%.
Molecular Weight

537.59

Formula

C28H28FN11
CAS No.
SMILES

CC1=CC(NC2=NNC(C)=C2)=NC(C3=CC=C(N4CC(C5)N(CC6=CC=C(N7C=C(F)C=N7)N=C6)C5C4)N=C3)=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RET-IN-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RET-IN-232479961-46-9RETInhibitorinhibitorinhibit

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