RET-IN-23
RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity.
For research use only. We do not sell to patients.
- CAS No.: 2479961-46-9
- Formula: C28H28FN11
- Molecular Weight:537.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.32 nM (RET-WT); 2.50 nM (RET-CCDC6); 6.54 nM (RET-V804L); 1.03 nM (RET-V804M); 1.47 nM (RET-M918T)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c-nu mouse (TT cell subcutaneous xenograft tumor)[1]
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Dosage:5 mg/kg
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Administration:P.o.
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Result:Showed anti-tumor activity with T/C of 17.44%, TGI of 88.82%.
Chemical Information
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CAS No. 2479961-46-9
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Molecular Weight 537.59
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Formula C28H28FN11
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SMILES
CC1=CC(NC2=NNC(C)=C2)=NC(C3=CC=C(N4CC(C5)N(CC6=CC=C(N7C=C(F)C=N7)N=C6)C5C4)N=C3)=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RET-IN-23 Related Classifications
HY-153676 Related Classifications
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