country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181895

Copy Link Print Information

RET degrader-1

RET degrader-1 is a HyT degrader targeting RET. RET degrader-1 induces the degradation of CCDC6-RET via the ubiquitin-proteasome pathway. RET degrader-1 can be used in the research of RET-driven cancers.
(Pink: RET ligand (HY-149539); Blue: HyT ligand (HY-W013021); Black: linker (HY-76667)).

For research use only. We do not sell to patients.

Formula: C₃₃H₃₇FN₆O₃
Molecular Weight:584.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RET degrader-1 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

RET degrader-1 is a HyT degrader targeting RET. RET degrader-1 induces the degradation of CCDC6-RET via the ubiquitin-proteasome pathway. RET degrader-1 can be used in the research of RET-driven cancers^[1]. (Pink: RET ligand (HY-149539); Blue: HyT ligand (HY-W013021); Black: linker (HY-76667)).

In Vitro

RET degrader-1 (Compound B2) (1-10 μM; 48 h) achieves a 91.4% degradation rate of the CCDC6-RET fusion protein in TPC-1 cells, while the degradation rate observed at a concentration of 1 μM after 48 h of treatment is less than 20%^[1].
RET degrader-1 (24-48 h) degrades GFP-tagged CCDC6-RET in transiently transfected HEK293T cells, as evidenced by the reduction in fluorescence intensity at 24 h and 48 h after treatment^[1].
The degradation of the CCDC6-RET fusion protein in TPC-1 cells induced by RET degrader-1 is dependent on the ubiquitin-proteasome pathway, rather than the autophagy-lysosome pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

human TPC-1 cells
Concentration:

1 μM, 10 μM
Incubation Time:

48 h
Result:

Reduced CCDC6-RET fusion protein levels by less than 20% at 1 μM for 48 h.
Reduced CCDC6-RET fusion protein levels by 91.4% at 10 μM for 48 h.
Confirmed a marked reduction in RET protein levels at 10 μM.

Chemical Information

Molecular Weight 584.68
Formula C₃₃H₃₇FN₆O₃
SMILES

FC1=CC(/C2=C3\C(C4=C(C=CC=C4)N3)=N\OCCN(CC5)CCN5CCCNC(C6CC7CC6C=C7)=O)=C(C=C1)NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu N, et al. Design, synthesis, and activity evaluation of RET protein degradation based on PROTAC and HyTTD techniques. Bioorganic & medicinal chemistry letters. 2026 Jun;135:130588. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote