country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181895

Copy Link Print Information

PROTAC HyTTD Degrader-1

PROTAC HyTTD Degrader-1 (Compound B2) is a hydrophobic tag tethered degrader (HyTTD) targeting RET, as well as a degrader of the CCDC6-RET fusion protein. PROTAC HyTTD Degrader-1 induces the degradation of the CCDC6-RET fusion protein via the ubiquitin-proteasome pathway. PROTAC HyTTD Degrader-1 is applicable to the research of RET-driven cancers.
(Pink: RET ligand (HY-149539); Blue: Ligands for E3 Ligase ligand (HY-W013021); Black: linker (HY-76667)).

For research use only. We do not sell to patients.

Formula: C₃₃H₃₇FN₆O₃
Molecular Weight:584.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC HyTTD Degrader-1 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

PROTAC HyTTD Degrader-1 (Compound B2) is a hydrophobic tag tethered degrader (HyTTD) targeting RET, as well as a degrader of the CCDC6-RET fusion protein. PROTAC HyTTD Degrader-1 induces the degradation of the CCDC6-RET fusion protein via the ubiquitin-proteasome pathway. PROTAC HyTTD Degrader-1 is applicable to the research of RET-driven cancers^[1]. (Pink: RET ligand (HY-149539); Blue: Ligands for E3 Ligase ligand (HY-W013021); Black: linker (HY-76667)).

In Vitro

PROTAC HyTTD Degrader-1 (1-10 μM; 48 h) achieves 91.4% degradation of CCDC6-RET fusion protein in TPC-1 cells at 10 μM for 48 h, and less than 20% degradation at 1 μM for 48 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 584.68
Formula C₃₃H₃₇FN₆O₃
SMILES

FC1=CC(/C2=C3\C(C4=C(C=CC=C4)N3)=N\OCCN(CC5)CCN5CCCNC(C6CC7CC6C=C7)=O)=C(C=C1)NC2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xu N, et al. Design, synthesis, and activity evaluation of RET protein degradation based on PROTAC and HyTTD techniques. Bioorg Med Chem Lett. 2026;135:130588. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock