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Cat. No.: HY-149539

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PLM-101

PLM-101 is an orally available anticancer agent targeting FLT3 and RET with inhibitory activity against acute myeloid leukemia cells. PLM-101 inhibits RET, thereby inducing autophagic degradation of FLT3; and it inhibits the PI3K and Ras/ERK pathways, resulting in anti-leukemia activity. PLM-101 has anti-tumor efficacy in a mouse MV4-11 flank xenograft model (dose: 3, 10 mg/kg; po) and an allogeneic xenograft mouse model (dose: 40 mg/kg; po).

For research use only. We do not sell to patients.

Formula: C₂₂H₂₂FN₅O₂
Molecular Weight:407.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

PLM-101 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MOLM-14	GI₅₀	23.1 nM Compound: 9	Antiproliferative activity against human MOLM-14 cells harboring FLT3 ITD/D835Y double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human MOLM-14 cells harboring FLT3 ITD/D835Y double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay	[PMID: 35489222]
MOLM-14	GI₅₀	25.3 nM Compound: 9	Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human MOLM-14 cells assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay	[PMID: 35489222]
MOLM-14	GI₅₀	75.6 nM Compound: 9	Antiproliferative activity against human MOLM-14 cells harboring FLT3 ITD/F691L double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human MOLM-14 cells harboring FLT3 ITD/F691L double mutant assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay	[PMID: 35489222]
MV4-11	GI₅₀	3.69 nM Compound: 9	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by EZ-Cytox colorimetric assay	[PMID: 35489222]

In Vitro

PLM-101 (30 nM, 100 nM) suppresses the phosphorylation of AKT (phospho-S473) and p70S6K (phospho-T389) in the PI3K signaling pathway, as well as the phosphorylation of MEK (phospho-S217/S221) and ERK (phospho-T202/Y204) in the Ras signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 407.44
Formula C₂₂H₂₂FN₅O₂
SMILES

FC1=CC2=C(C=C1)NC(/C2=C3NC4=CC=CC=C4C\3=N/OCCN5CCNCC5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Choi YJ, et al. PLM-101 is a novel and potent FLT3/RET inhibitor with less adverse effects in the treatment of acute myeloid leukemia. Biomed Pharmacother. 2023 Sep;165:115066.. . [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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