3-(Boc-amino)propyl bromide
Based on 1 Customer Validation
3-(Boc-amino) propyl bromide is an alkylating reagent used for the N-alkylation of benzopyranotriazolopyrimidine-based MDM2-p53 protein-protein inhibitor 4 to prepare Compound 13.
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 83948-53-2
- Formula: C8H16BrNO2
- Molecular Weight:238.12
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Compound 13 inhibits the MDM2-p53 protein-protein interaction with an HTRF IC50 of 4.4 μM; it fails to induce p21 expression in SJSA-1 cells at concentrations up to 50 μM, and shows a residual rate of 44% after incubation with rat liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 83948-53-2
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Appearance <37°C Solid, >39°C Liquid
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Molecular Weight 238.12
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Formula C8H16BrNO2
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Color Off-white to light yellow
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SMILES
O=C(NCCCBr)OC(C)(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (419.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1996 mL | 20.9978 mL | 41.9956 mL | 104.9891 mL |
| 5 mM | 0.8399 mL | 4.1996 mL | 8.3991 mL | 20.9978 mL | |
| 10 mM | 0.4200 mL | 2.0998 mL | 4.1996 mL | 10.4989 mL | |
| 15 mM | 0.2800 mL | 1.3999 mL | 2.7997 mL | 6.9993 mL | |
| 20 mM | 0.2100 mL | 1.0499 mL | 2.0998 mL | 5.2495 mL | |
| 25 mM | 0.1680 mL | 0.8399 mL | 1.6798 mL | 4.1996 mL | |
| 30 mM | 0.1400 mL | 0.6999 mL | 1.3999 mL | 3.4996 mL | |
| 40 mM | 0.1050 mL | 0.5249 mL | 1.0499 mL | 2.6247 mL | |
| 50 mM | 0.0840 mL | 0.4200 mL | 0.8399 mL | 2.0998 mL | |
| 60 mM | 0.0700 mL | 0.3500 mL | 0.6999 mL | 1.7498 mL | |
| 80 mM | 0.0525 mL | 0.2625 mL | 0.5249 mL | 1.3124 mL | |
| 100 mM | 0.0420 mL | 0.2100 mL | 0.4200 mL | 1.0499 mL |
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