3-(Boc-amino)propyl bromide

Cat. No.: HY-76667 Purity: 99.95%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

3-(Boc-amino) propyl bromide is an alkylating reagent used for the N-alkylation of benzopyranotriazolopyrimidine-based MDM2-p53 protein-protein inhibitor 4 to prepare Compound 13.

For research use only. We do not sell to patients.

3-(Boc-amino)propyl bromide Chemical Structure

CAS No. : 83948-53-2

Size	Stock	Quantity
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid or liquid
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
> 100 g	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

3-(Boc-amino) propyl bromide is an alkylating reagent used for the N-alkylation of benzopyranotriazolopyrimidine-based MDM2-p53 protein-protein inhibitor 4 to prepare Compound 13^[1].

In Vitro

Compound 13 inhibits the MDM2-p53 protein-protein interaction with an HTRF IC₅₀ of 4.4 μM; it fails to induce p21 expression in SJSA-1 cells at concentrations up to 50 μM, and shows a residual rate of 44% after incubation with rat liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

238.12

Formula

C₈H₁₆BrNO₂

CAS No.

83948-53-2

Appearance

<37°C Solid,>39°C Liquid

Color

Off-white to light yellow

SMILES

O=C(NCCCBr)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (419.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1996 mL	20.9978 mL	41.9956 mL
5 mM	0.8399 mL	4.1996 mL	8.3991 mL
10 mM	0.4200 mL	2.0998 mL	4.1996 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (269 KB) SDS (394 KB)

COA (244 KB) HNMR (117 KB) GC (212 KB)

Handling Instructions (2659 KB)

References

[1]. Beck HP, et al. Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors. Bioorg Med Chem Lett. 2011;21(9):2752-2755. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1996 mL	20.9978 mL	41.9956 mL	104.9891 mL
	5 mM	0.8399 mL	4.1996 mL	8.3991 mL	20.9978 mL
	10 mM	0.4200 mL	2.0998 mL	4.1996 mL	10.4989 mL
	15 mM	0.2800 mL	1.3999 mL	2.7997 mL	6.9993 mL
	20 mM	0.2100 mL	1.0499 mL	2.0998 mL	5.2495 mL
	25 mM	0.1680 mL	0.8399 mL	1.6798 mL	4.1996 mL
	30 mM	0.1400 mL	0.6999 mL	1.3999 mL	3.4996 mL
	40 mM	0.1050 mL	0.5249 mL	1.0499 mL	2.6247 mL
	50 mM	0.0840 mL	0.4200 mL	0.8399 mL	2.0998 mL
	60 mM	0.0700 mL	0.3500 mL	0.6999 mL	1.7498 mL
	80 mM	0.0525 mL	0.2625 mL	0.5249 mL	1.3124 mL
	100 mM	0.0420 mL	0.2100 mL	0.4200 mL	1.0499 mL