2. Immunology/Inflammation Stem Cell/Wnt Cell Cycle/DNA Damage
  3. IKZF Family Casein Kinase
  4. Sontigidomide

Sontigidomide is a protein degrader that can effectively degrade IKAROS and GSPT1 proteins.. Sontigidomide can be used to study inflammatory and immune system diseases.

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Sontigidomide

Sontigidomide 構造式

CAS 番号 : 2560577-69-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 384 在庫あり
Solution
10 mM * 1 mL in DMSO USD 384 在庫あり
Solid
5 mg $340 在庫あり
10 mg $550 在庫あり
25 mg $1100 在庫あり
50 mg $1780 在庫あり
100 mg $2840 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Sontigidomide 関連抗体

Top Publications Citing Use of Products

IKZF Family アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IKZF1 IKZF2 IKZF3 IKZF4

Casein Kinase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CK1 CK2

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Sontigidomide is a protein degrader that can effectively degrade IKAROS and GSPT1 proteins.. Sontigidomide can be used to study inflammatory and immune system diseases[1].

IC50 & Target[1]

IKZF1

 

体外実験

Sontigidomide (Compound I-5) (0.1 μM) exhibits a degradation rate of over 80% for IKAROS and GSPT1 proteins and a degradation rate of 25%-50% for CK1α protein[1].
Sontigidomide (1 μM; 3 days) exhibits an antiproliferative activity of over 80% for MOLM-13 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sontigidomide 関連抗体

Cell Proliferation Assay[1]

Cell Line: MOLM-13 cells
Concentration: 1 μM
Incubation Time: 3 days
Result: Exhibited an antiproliferative activity of over 80%.
分子量

513.47

分子式

C26H22F3N3O5
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=CC=C(C2(C(F)(F)F)CC2)C=C1)=O)NCC3=CC=C4C(N(C5C(NC(CC5)=O)=O)CC4=C3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (243.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9475 mL 9.7377 mL 19.4753 mL
5 mM 0.3895 mL 1.9475 mL 3.8951 mL
10 mM 0.1948 mL 0.9738 mL 1.9475 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 98.62%

COA (248 KB) HNMR (269 KB) LCMS (87 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9475 mL 9.7377 mL 19.4753 mL 48.6883 mL
5 mM 0.3895 mL 1.9475 mL 3.8951 mL 9.7377 mL
10 mM 0.1948 mL 0.9738 mL 1.9475 mL 4.8688 mL
15 mM 0.1298 mL 0.6492 mL 1.2984 mL 3.2459 mL
20 mM 0.0974 mL 0.4869 mL 0.9738 mL 2.4344 mL
25 mM 0.0779 mL 0.3895 mL 0.7790 mL 1.9475 mL
30 mM 0.0649 mL 0.3246 mL 0.6492 mL 1.6229 mL
40 mM 0.0487 mL 0.2434 mL 0.4869 mL 1.2172 mL
50 mM 0.0390 mL 0.1948 mL 0.3895 mL 0.9738 mL
60 mM 0.0325 mL 0.1623 mL 0.3246 mL 0.8115 mL
80 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6086 mL
100 mM 0.0195 mL 0.0974 mL 0.1948 mL 0.4869 mL
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Sontigidomide Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sontigidomide2560577-69-5IKZF FamilyCasein KinaseIkaros zinc finger protein familyprotein-mediated diseasesprotein homeostasisInhibitorinhibitorinhibit

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製品名:
Sontigidomide
製品番号:
HY-156641
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