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Cat. No.: HY-182797

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NHWL071065

NHWL071065 is a CRBN-targeting IKZF1/IKZF3 molecular glues degrader. NHWL071065 selectively degrades IKZF1 and IKZF3 in lymphoma cells via the ubiquitin-proteasome pathway. NHWL071065 inhibits the proliferation of lymphoma cells. NHWL071065 downregulates proteins involved in cytoskeleton assembly, cell adhesion and immune regulation in cells, while upregulating proteins related to the type I IFN signaling pathway. NHWL071065 can be used in the research of lymphoma.

For research use only. We do not sell to patients.

CAS No.: 3117340-01-6
Formula: C₃₁H₃₇FN₆O₄
Molecular Weight:576.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NHWL071065 Chemical Structure

CAS No.: 3117340-01-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IKZF1

IKZF3

All IKZF Family Isoforms :

In Vitro

NHWL071065 (Compound 26) (3 days) potently inhibits the proliferation of TMD8 cells (IC₅₀ = 6.6 nM) and WSU-DLCL2 cells (IC₅₀ = 2.6 nM), but shows no inhibitory activity against MKN28, PANC-1, LO2 or HUVEC cells^[1].
NHWL071065 (1.25-40 nM, 0.313-5 μM; 16 h) potently and selectively degrades IKZF1 (DC₅₀ = 1.8 nM) and IKZF3 (DC₅₀ = 14.9 nM) in TMD8 cells, induces concentration-dependent degradation of IKZF1/IKZF3 in WSU-DLCL2 cells, and does not degrade PDE6D, SALL4 or GSPT1^[1].
NHWL071065 (100 nM; 6 h) significantly downregulates IKZF1/IKZF3 and proteins involved in cytoskeleton assembly, cell adhesion and immune regulation in TMD8 cells, while upregulating proteins related to the type I interferon signaling pathway, but exerts no significant effects on GSPT1, NEK7 or CK1α^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

TMD8 lymphoma cells, WSU-DLCL2 lymphoma cells
Concentration:

1.25, 2.5, 5, 10, 20, 40 nM (TMD8 cells, IKZF1/IKZF3); 1, 5, 10, 50 nM (WSU-DLCL2 cells, IKZF1/IKZF3); 0.313, 0.625, 1.25, 2.5, 5 μM (TMD8 cells, PDE6D/SALL4); 1, 5, 10, 50 nM (TMD8 cells, GSPT1)
Incubation Time:

16 h
Result:

Achieved a DC₅₀ of 1.8 nM for IKZF1 degradation and 14.9 nM for IKZF3 degradation in TMD8 cells, with near-complete degradation at 40 nM.
Concentration-dependently degraded both IKZF1 and IKZF3 in WSU-DLCL2 cells, with significant reduction observed at 1 nM.
Did not degrade PDE6D (up to 5 μM), SALL4 (up to 2.5 μM), or GSPT1 (at concentrations that potently degrade IKZF1/3) in TMD8 cells.

Parmacokinetics

Species	Dose	Route	AUC_0-∞	MRT_0-∞	T_1/2β	T_max	V_z	C_max
Rat^[1]	2 mg/kg	i.v.	1078.319 μg/L·h	5.807 h	6.395 h	/	17.456 L/kg	2330 μg/L
Rat^[1]	10 mg/kg	p.o.	1105.037 μg/L·h	8.046 h	5.913 h	0.667 h	77.406 L/kg	157.667 μg/L

Chemical Information

CAS No. 3117340-01-6
Molecular Weight 576.66
Formula C₃₁H₃₇FN₆O₄
SMILES

O=C(C(N1C(C)=NC2=C(C(NCC3=CC=C(CN4CCC(N5CCOCC5)CC4)C=C3F)=CC=C2)C1=O)CC6)NC6=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen P, et al. Optimization of novel quinazolinone derivatives as CRBN E3 ligase modulators for enhanced degradative activity and metabolic stability. Bioorg Chem. 2026;175:109816. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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