3117340-01-6
Chemical Structure
NHWL071065
- CAS No.: 3117340-01-6
- Formula:C31H37FN6O4
- Molecular Weight:576.66
InChIKey: BAFAKFJKCUIVCB-UHFFFAOYSA-N
SMILES: O=C(C(N1C(C)=NC2=C(C(NCC3=CC=C(CN4CCC(N5CCOCC5)CC4)C=C3F)=CC=C2)C1=O)CC6)NC6=O
Biological Activity: NHWL071065 is a CRBN-targeting IKZF1/IKZF3 molecular glues degrader. NHWL071065 selectively degrades IKZF1 and IKZF3 in lymphoma cells via the ubiquitin-proteasome pathway. NHWL071065 inhibits the proliferation of lymphoma cells. NHWL071065 downregulates proteins involved in cytoskeleton assembly, cell adhesion and immune regulation in cells, while upregulating proteins related to the type I IFN signaling pathway. NHWL071065 can be used in the research of lymphoma[1].
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NHWL071065 | NHWL071065 is a CRBN-targeting IKZF1/IKZF3 molecular glues degrader. NHWL071065 selectively degrades IKZF1 and IKZF3 in lymphoma cells via the ubiquitin-proteasome pathway. NHWL071065 inhibits the proliferation of lymphoma cells. NHWL071065 downregulates proteins involved in cytoskeleton assembly, cell adhesion and immune regulation in cells, while upregulating proteins related to the type I IFN signaling pathway. NHWL071065 can be used in the research of lymphoma. | |||||||||||||||||||||
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