2. PROTAC Immunology/Inflammation Apoptosis
  3. Molecular Glues IKZF Family Apoptosis
  4. DIX-01

DIX-01 is a molecular gel degrader that can simultaneously induce the degradation of IKZF1/3 and GSPT1 mediated by CRBN. Its DC50 values are: IKZF1 (19.80 nM), IKZF3 (45.31 nM), and GSPT1 (120.1 nM). DIX-01 exhibits nanomolar-level potent anti-proliferative activity in various cancer cell lines. DIX-01 induces apoptosis in MV4-11 cells and significantly inhibits the growth of leukemia cells in zebrafish. DIX-01 can be used for the study of malignant hematological tumors.

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DIX-01

DIX-01 Chemical Structure

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DIX-01 Related Antibodies

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IKZF1 IKZF2 IKZF3 IKZF4

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Description

DIX-01 is a molecular gel degrader that can simultaneously induce the degradation of IKZF1/3 and GSPT1 mediated by CRBN. Its DC50 values are: IKZF1 (19.80 nM), IKZF3 (45.31 nM), and GSPT1 (120.1 nM). DIX-01 exhibits nanomolar-level potent anti-proliferative activity in various cancer cell lines. DIX-01 induces apoptosis in MV4-11 cells and significantly inhibits the growth of leukemia cells in zebrafish. DIX-01 can be used for the study of malignant hematological tumors[1].

IC50 & Target[1]

IKZF1

19.80 nM (DC50)

IKZF3

45.31 nM (DC50)

Molecular Weight

538.59

Formula

C31H30N4O5
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOC4=CC5=C(C=C4)CN(C)C6=C(CC)C=CC=C56)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DIX-01 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DIX-01DIX01DIX 01Molecular GluesIKZF FamilyApoptosisIkaros zinc finger protein familyMolecular glueIKZF1/3GSPT1Dual-targetAcute myelogenous leukemiaMolecular dynamics simulationInhibitorinhibitorinhibit

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