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Cat. No.: HY-179077

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PROTAC BTK/IKZF1/3 Degrader-1

PROTAC BTK/IKZF1/3 Degrader-1 is a selective and orally active BCL6 and IKZF1/3 PROTAC degrader. PROTAC BTK/IKZF1/3 Degrader-1 exhibits antitumor activity. PROTAC BTK/IKZF1/3 Degrader-1 can be used for the research of cancer, such as lymphoma. (Structure Note: Pink: BCL6/IKZF1/3 ligand (HY-179076); Blue: CRBN ligand (HY-41547))
(Pink: Btk and IKZF1 and IKZF3 ligand (HY-179076); Blue: Cereblon ligand (HY-41547); Black: linker).

For research use only. We do not sell to patients.

CAS No.: 2416130-49-7
Formula: C₄₃H₅₁N₁₁O₆
Molecular Weight:817.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PROTAC BTK/IKZF1/3 Degrader-1 Chemical Structure

CAS No.: 2416130-49-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
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Biological Activity

Description

PROTAC BTK/IKZF1/3 Degrader-1 is a selective and orally active BCL6 and IKZF1/3 PROTAC degrader. PROTAC BTK/IKZF1/3 Degrader-1 exhibits antitumor activity. PROTAC BTK/IKZF1/3 Degrader-1 can be used for the research of cancer, such as lymphoma^[1]. (Structure Note: Pink: BCL6/IKZF1/3 ligand (HY-179076); Blue: CRBN ligand (HY-41547)) (Pink: Btk and IKZF1 and IKZF3 ligand (HY-179076); Blue: Cereblon ligand (HY-41547); Black: linker).

IC₅₀ & Target^[1]

IKZF1

IKZF3

Cereblon

All PROTACs Isoforms :

All IKZF Family Isoforms :

In Vitro

PROTAC BTK/IKZF1/3 Degrader-1 (Compound BT6) (1-300 nM, 24 h) concentration-dependently degrades BTK and IKZF1/3 proteins (BTK degradation rate exceeds 75% at 33.3 nM, IKZF1/3 degradation rate exceeds 50% at 300 nM) in diffuse large B-cell lymphoma (DLBCL) cells including Mino and OCI-ly10^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PROTAC BTK/IKZF1/3 Degrader-1 ( Compound BT6) (1-300 nM, 24 h) (3-10 mg/kg, p.o., daily for 21 days) significantly inhibits tumor growth with tumor growth in NOD-SCID mice bearing OCI-ly10 xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-week-old female NOD-SCID mice bearing OCI-ly1 xenografts^[1]
Dosage:

3 and 10 mg/kg
Administration:

Orally administration, daily for 21 days
Result:

Showed tumor growth inhibition (TGI) rates of 95.54% and 115.72%.
Degraded BTK and IKZF1/3 proteins in tumor tissues.
Showed no significant body weight changes.

Chemical Information

CAS No. 2416130-49-7
Molecular Weight 817.94
Formula C₄₃H₅₁N₁₁O₆
SMILES

CN1CCN(C1=O)[C@@H]2CCCN(C2)C3=CN=C(C(NC4=CC=C(C=C4)C5CCN(CC5)CC6CCN(C6)C7=CC8=C(C(N(C8=O)C9CCC(NC9=O)=O)=O)C=C7)=N3)C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jin Y, et al. Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma. J Med Chem. 2025 Oct 23;68(20):21249-21281. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PROTAC BTK/IKZF1/3 Degrader-1

All PROTACs Isoforms

All IKZF Family Isoforms