2416130-49-7
Chemical Structure
PROTAC BTK/IKZF1/3 Degrader-1
- CAS No.: 2416130-49-7
- Formula:C43H51N11O6
- Molecular Weight:817.94
InChIKey: WFDYOAWNEOGIPM-XORRCSPGSA-N
SMILES: CN1CCN(C1=O)[C@@H]2CCCN(C2)C3=CN=C(C(NC4=CC=C(C=C4)C5CCN(CC5)CC6CCN(C6)C7=CC8=C(C(N(C8=O)C9CCC(NC9=O)=O)=O)C=C7)=N3)C(N)=O
Biological Activity: PROTAC BTK/IKZF1/3 Degrader-1 is an orally active PROTAC-IMiD bifunctional protein degrader that selectively degrades BTK, IKZF1 and IKZF3. PROTAC BTK/IKZF1/3 Degrader-1 recruits the CRBN E3 ubiquitin ligase to form a ternary complex, mediating ubiquitination and proteasome-dependent degradation of target proteins, with no obvious degrading effect on GSPT1. PROTAC BTK/IKZF1/3 Degrader-1 inhibits cancer cell proliferation, induces cancer cell apoptosis, and suppresses tumor growth. PROTAC BTK/IKZF1/3 Degrader-1 can be used for the research of diffuse large B-cell lymphoma[1].
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PROTAC BTK/IKZF1/3 Degrader-1 | PROTAC BTK/IKZF1/3 Degrader-1 is an orally active PROTAC-IMiD bifunctional protein degrader that selectively degrades BTK, IKZF1 and IKZF3. PROTAC BTK/IKZF1/3 Degrader-1 recruits the CRBN E3 ubiquitin ligase to form a ternary complex, mediating ubiquitination and proteasome-dependent degradation of target proteins, with no obvious degrading effect on GSPT1. PROTAC BTK/IKZF1/3 Degrader-1 inhibits cancer cell proliferation, induces cancer cell apoptosis, and suppresses tumor growth. PROTAC BTK/IKZF1/3 Degrader-1 can be used for the research of diffuse large B-cell lymphoma. | |||||||||||||||||||||
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